TY - JOUR
T1 - Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis
AU - Uc, Aliye
AU - Zimmerman, M. Bridget
AU - Wilschanski, Michael
AU - Werlin, Steven L.
AU - Troendle, David
AU - Shah, Uzma
AU - Schwarzenberg, Sarah Jane
AU - Rhee, Sue
AU - Pohl, John F.
AU - Perito, Emily R.
AU - Palermo, Joseph J.
AU - Ooi, Chee Y.
AU - Liu, Quin
AU - Lin, Tom K.
AU - Morinville, Veronique D.
AU - McFerron, Brian A.
AU - Husain, Sohail Z.
AU - Himes, Ryan
AU - Heyman, Melvin B.
AU - Gonska, Tanja
AU - Giefer, Matthew J.
AU - Gariepy, Cheryl E.
AU - Freedman, Steven D.
AU - Fishman, Douglas S.
AU - Bellin, Melena D.
AU - Barth, Bradley
AU - Abu-El-Haija, Maisam
AU - Lowe, Mark E.
N1 - Funding Information:
A.U. is supported by the National Institutes of Health grants (R21 DK096327, U01 DK108334, R01 DK097820); INSPPIRE registry was developed by CTSA (2UL1 TR000442) and REDCap.
Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.
AB - Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.
KW - body mass index
KW - children
KW - pancreatitis
UR - http://www.scopus.com/inward/record.url?scp=85051951074&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000001120
DO - 10.1097/MPA.0000000000001120
M3 - Article
C2 - 30059474
AN - SCOPUS:85051951074
SN - 0885-3177
VL - 47
SP - 967
EP - 973
JO - Pancreas
JF - Pancreas
IS - 8
ER -