Impact of intraoperative magnetic resonance imaging and other factors on surgical outcomes for newly diagnosed grade II astrocytomas and oligodendrogliomas: A multicenter study

Alexander T. Yahanda, Bhuvic Patel, Amar S. Shah, Daniel P. Cahill, Garnette Sutherland, John Honeycutt, Randy L. Jensen, Keith M. Rich, Joshua L. Dowling, David D. Limbrick, Ralph G. Dacey, Albert H. Kim, Eric C. Leuthardt, Gavin P. Dunn, Gregory J. Zipfel, Jeffrey R. Leonard, Matthew D. Smyth, Mitesh V. Shah, Steven R. Abram, John EvansMichael R. Chicoine

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

BACKGROUND: Few studies use large, multi-institutional patient cohorts to examine the role of intraoperative magnetic resonance imaging (iMRI) in the resection of grade II gliomas. OBJECTIVE: To assess the impact of iMRI and other factors on overall survival (OS) and progression-free survival (PFS) for newly diagnosed grade II astrocytomas and oligodendrogliomas. METHODS: Retrospective analyses of a multicenter database assessed the impact of patient-, treatment-, and tumor-related factors on OS and PFS. RESULTS: A total of 232 resections (112 astrocytomas and 120 oligodendrogliomas) were analyzed. Oligodendrogliomas had longer OS (P < .001) and PFS (P = .01) than astrocytomas. Multivariate analyses demonstrated improved OS for gross total resection (GTR) vs subtotal resection (STR; P = .006, hazard ratio [HR]: .23) and near total resection (NTR; P = .02, HR: .64). GTR vs STR (P = .02, HR: .54), GTR vs NTR (P = .04, HR: .49), and iMRI use (P = .02, HR: .54) were associated with longer PFS. Frontal (P = .048, HR: 2.11) and occipital/parietal (P = .003, HR: 3.59) locations were associated with shorter PFS (vs temporal). Kaplan-Meier analyses showed longer OS with increasing extent of surgical resection (EOR) (P = .03) and 1p/19q gene deletions (P = .02). PFS improved with increasing EOR (P = .01), GTR vs NTR (P = .02), and resections above STR (P = .04). Factors influencing adjuvant treatment (35.3% of patients) included age (P = .002, odds ratio [OR]: 1.04) and EOR (P = .003, OR: .39) but not glioma subtype or location. Additional tumor resection after iMRI was performed in 105/159 (66%) iMRI cases, yielding GTR in 54.5% of these instances. CONCLUSION: EOR is a major determinant of OS and PFS for patients with grade II astrocytomas and oligodendrogliomas. Intraoperative MRI may improve EOR and was associated with increased PFS.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalNeurosurgery
Volume88
Issue number1
DOIs
StatePublished - Jan 1 2021

Keywords

  • Astrocytoma
  • Extent of resection
  • Grade II glioma
  • Intraoperative magnetic resonance imaging
  • Low-grade glioma
  • Oligodendroglioma

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