Impact of Genotyping on Selection of Red Blood Cell Donors for Transfusion

Ronald Jackups

doi:10.1016/j.hoc.2019.05.005

Impact of Genotyping on Selection of Red Blood Cell Donors for Transfusion

Ronald Jackups

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Red blood cell (RBC) antigen phenotyping is an essential component of transfusion compatibility testing. Serology has been the gold standard method, but its low throughput and risk of diagnostic interference in certain situations limits its applicability. Genotyping is useful for phenotyping in these cases, providing a high-throughput and reliable alternative to serology. Genotyping is indicated in several hematology and oncology patient populations. Because genotyping requires a complex testing environment and bears an additional risk of genotype-phenotype discrepancy, its use is currently limited, but it serves as a useful adjunct and may eventually supplant serology as a new gold standard.

Original language	English
Pages (from-to)	813-823
Number of pages	11
Journal	Hematology/Oncology Clinics of North America
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.hoc.2019.05.005
State	Published - Oct 2019

Keywords

RBC antigen genotyping
RBC antigen phenotype
RBC antigen serology
RBC donor selection

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title = "Impact of Genotyping on Selection of Red Blood Cell Donors for Transfusion",

abstract = "Red blood cell (RBC) antigen phenotyping is an essential component of transfusion compatibility testing. Serology has been the gold standard method, but its low throughput and risk of diagnostic interference in certain situations limits its applicability. Genotyping is useful for phenotyping in these cases, providing a high-throughput and reliable alternative to serology. Genotyping is indicated in several hematology and oncology patient populations. Because genotyping requires a complex testing environment and bears an additional risk of genotype-phenotype discrepancy, its use is currently limited, but it serves as a useful adjunct and may eventually supplant serology as a new gold standard.",

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AB - Red blood cell (RBC) antigen phenotyping is an essential component of transfusion compatibility testing. Serology has been the gold standard method, but its low throughput and risk of diagnostic interference in certain situations limits its applicability. Genotyping is useful for phenotyping in these cases, providing a high-throughput and reliable alternative to serology. Genotyping is indicated in several hematology and oncology patient populations. Because genotyping requires a complex testing environment and bears an additional risk of genotype-phenotype discrepancy, its use is currently limited, but it serves as a useful adjunct and may eventually supplant serology as a new gold standard.

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KW - RBC antigen serology

KW - RBC donor selection

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Impact of Genotyping on Selection of Red Blood Cell Donors for Transfusion

Abstract

Keywords

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