Impact of Genotyping on Selection of Red Blood Cell Donors for Transfusion

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Red blood cell (RBC) antigen phenotyping is an essential component of transfusion compatibility testing. Serology has been the gold standard method, but its low throughput and risk of diagnostic interference in certain situations limits its applicability. Genotyping is useful for phenotyping in these cases, providing a high-throughput and reliable alternative to serology. Genotyping is indicated in several hematology and oncology patient populations. Because genotyping requires a complex testing environment and bears an additional risk of genotype-phenotype discrepancy, its use is currently limited, but it serves as a useful adjunct and may eventually supplant serology as a new gold standard.

Original languageEnglish
Pages (from-to)813-823
Number of pages11
JournalHematology/Oncology Clinics of North America
Volume33
Issue number5
DOIs
StatePublished - Oct 2019

Keywords

  • RBC antigen genotyping
  • RBC antigen phenotype
  • RBC antigen serology
  • RBC donor selection

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