TY - JOUR
T1 - Impact of Genotyping on Selection of Red Blood Cell Donors for Transfusion
AU - Jackups, Ronald
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - Red blood cell (RBC) antigen phenotyping is an essential component of transfusion compatibility testing. Serology has been the gold standard method, but its low throughput and risk of diagnostic interference in certain situations limits its applicability. Genotyping is useful for phenotyping in these cases, providing a high-throughput and reliable alternative to serology. Genotyping is indicated in several hematology and oncology patient populations. Because genotyping requires a complex testing environment and bears an additional risk of genotype-phenotype discrepancy, its use is currently limited, but it serves as a useful adjunct and may eventually supplant serology as a new gold standard.
AB - Red blood cell (RBC) antigen phenotyping is an essential component of transfusion compatibility testing. Serology has been the gold standard method, but its low throughput and risk of diagnostic interference in certain situations limits its applicability. Genotyping is useful for phenotyping in these cases, providing a high-throughput and reliable alternative to serology. Genotyping is indicated in several hematology and oncology patient populations. Because genotyping requires a complex testing environment and bears an additional risk of genotype-phenotype discrepancy, its use is currently limited, but it serves as a useful adjunct and may eventually supplant serology as a new gold standard.
KW - RBC antigen genotyping
KW - RBC antigen phenotype
KW - RBC antigen serology
KW - RBC donor selection
UR - http://www.scopus.com/inward/record.url?scp=85068252255&partnerID=8YFLogxK
U2 - 10.1016/j.hoc.2019.05.005
DO - 10.1016/j.hoc.2019.05.005
M3 - Review article
C2 - 31466606
AN - SCOPUS:85068252255
VL - 33
SP - 813
EP - 823
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 5
ER -