TY - JOUR
T1 - Impact of Elevated Serum Triglycerides on Children with Acute Recurrent or Chronic Pancreatitis from INSPPIRE-2
AU - Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer
AU - Sellers, Zachary M.
AU - Giefer, Matthew J.
AU - Wang, Fuchenchu
AU - Cress, Gretchen A.
AU - Abu-El-Haija, Maisam A.
AU - Chugh, Ankur
AU - Cohen, Reuven Z.
AU - Downs, Elissa M.
AU - Fishman, Douglas S.
AU - Freeman, A. Jay
AU - Gariepy, Cheryl E.
AU - Gonska, Tanja Y.
AU - Grover, Amit S.
AU - Lindblad, Doug
AU - Liu, Quin Y.
AU - Maqbool, Asim
AU - Mark, Jacob A.
AU - McFerron, Brian A.
AU - Mehta, Megha S.
AU - Morinville, Veronique D.
AU - Ng, Kenneth
AU - Noel, Robert A.
AU - Ooi, Chee Y.
AU - Perito, Emily R.
AU - Phadke, Madhura Y.
AU - Ruan, Wenly
AU - Schwarzenberg, Sarah Jane
AU - Troendle, David M.
AU - Wilschanski, Michael
AU - Zheng, Yuhua
AU - Yuan, Ying
AU - Lowe, Mark E.
AU - Uc, Aliye
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2025/1
Y1 - 2025/1
N2 - Objective: To determine if mild-moderate hypertriglyceridemia (HTG) is associated with increased development of chronic pancreatitis (CP) or pancreatitis-associated complications in children with acute recurrent or CP. Study design: Longitudinal data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2) cohort of children with acute recurrent or CP (n = 559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.7 mmol/L), any HTG (≥150 mg/dL; ≥1.7 mmol/L), mild-moderate HTG (150-499 mg/dL; 1.7-5.6 mmol/L), moderate HTG (500-999 mg/dL; 5.6-11.3 mmol/L), and severe HTG groups (≥1000 mg/dL; ≥11.3 mmol/L), based on highest serum triglyceride value. Laboratory, imaging, pancreatitis and hospital events, complications, and quality of life data were analyzed. Results: In children with acute recurrent or CP and HTG, there was no increase in the number of pancreatitis attacks per person-years, nor an increase in CP prevalence. However, HTG severity was associated with increased pancreatic inflammation, pancreatic cysts, pain, hospital days, number of hospitalizations, intensive care, and missed school days. Conclusions: Mild-moderate HTG in children with acute recurrent or CP was not associated with increased pancreatitis frequency, nor increased development of CP, but was associated with increased pancreatitis complications and disease burden. As a treatable condition, treatment of mild-moderate HTG may be considered to reduce pancreatitis-associated complications and medical burden in children with acute recurrent or CP.
AB - Objective: To determine if mild-moderate hypertriglyceridemia (HTG) is associated with increased development of chronic pancreatitis (CP) or pancreatitis-associated complications in children with acute recurrent or CP. Study design: Longitudinal data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2) cohort of children with acute recurrent or CP (n = 559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.7 mmol/L), any HTG (≥150 mg/dL; ≥1.7 mmol/L), mild-moderate HTG (150-499 mg/dL; 1.7-5.6 mmol/L), moderate HTG (500-999 mg/dL; 5.6-11.3 mmol/L), and severe HTG groups (≥1000 mg/dL; ≥11.3 mmol/L), based on highest serum triglyceride value. Laboratory, imaging, pancreatitis and hospital events, complications, and quality of life data were analyzed. Results: In children with acute recurrent or CP and HTG, there was no increase in the number of pancreatitis attacks per person-years, nor an increase in CP prevalence. However, HTG severity was associated with increased pancreatic inflammation, pancreatic cysts, pain, hospital days, number of hospitalizations, intensive care, and missed school days. Conclusions: Mild-moderate HTG in children with acute recurrent or CP was not associated with increased pancreatitis frequency, nor increased development of CP, but was associated with increased pancreatitis complications and disease burden. As a treatable condition, treatment of mild-moderate HTG may be considered to reduce pancreatitis-associated complications and medical burden in children with acute recurrent or CP.
KW - lipids
KW - pancreas
KW - pediatric
KW - triglycerides
UR - http://www.scopus.com/inward/record.url?scp=85205455137&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2024.114298
DO - 10.1016/j.jpeds.2024.114298
M3 - Article
C2 - 39277078
AN - SCOPUS:85205455137
SN - 0022-3476
VL - 276
JO - Journal of Pediatrics
JF - Journal of Pediatrics
M1 - 114298
ER -