TY - JOUR
T1 - Impact of Clostridium difficile recurrence on hospital readmissions
AU - Olsen, Margaret A.
AU - Yan, Yan
AU - Reske, Kimberly A.
AU - Zilberberg, Marya
AU - Dubberke, Erik R.
N1 - Funding Information:
Funding/Support: This work was supported by a grant from Cubist Pharmaceuticals , Lexington, MA.
Publisher Copyright:
Copyright © 2015 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Background: The impact of recurrent Clostridium difficile infections (CDIs) on hospital readmissions is unknown. The objective of this study was to determine whether recurrent CDI was independently associated with the number of hospital readmissions and days readmitted. Methods: We performed a retrospective cohort study at an academic, urban, tertiary care hospital. Data were collected from electronic medical records and supplemented with chart review. CDI patients were followed for 180 days to ascertain the number of hospital readmissions and total days readmitted. Univariate and multivariable negative binomial regression models were used to evaluate factors, including CDI recurrence, associated with hospital readmissions. Results: The study included 3,950 patients with CDI from 2003-2009, including 413 patients with recurrent CDI. Recurrent CDI patients were significantly more likely to have at least 1 readmission (85% vs 41%; P < .001) and had more days readmitted (mean = 18.6 vs 7.6; P < .001) than patients without recurrent CDI. In multivariable analysis, recurrent CDI was independently associated with number of readmissions (rate ratio = 2.54; 95% confidence interval [CI], 2.21-2.91) and days readmitted (rate ratio = 3.97; 95% CI, 3.11-5.08) after adjustment for demographics, comorbidities, and medications. Conclusion: Recurrent CDI patients are significantly more likely than patients without a recurrence to be readmitted and spend increased time readmitted to the hospital.
AB - Background: The impact of recurrent Clostridium difficile infections (CDIs) on hospital readmissions is unknown. The objective of this study was to determine whether recurrent CDI was independently associated with the number of hospital readmissions and days readmitted. Methods: We performed a retrospective cohort study at an academic, urban, tertiary care hospital. Data were collected from electronic medical records and supplemented with chart review. CDI patients were followed for 180 days to ascertain the number of hospital readmissions and total days readmitted. Univariate and multivariable negative binomial regression models were used to evaluate factors, including CDI recurrence, associated with hospital readmissions. Results: The study included 3,950 patients with CDI from 2003-2009, including 413 patients with recurrent CDI. Recurrent CDI patients were significantly more likely to have at least 1 readmission (85% vs 41%; P < .001) and had more days readmitted (mean = 18.6 vs 7.6; P < .001) than patients without recurrent CDI. In multivariable analysis, recurrent CDI was independently associated with number of readmissions (rate ratio = 2.54; 95% confidence interval [CI], 2.21-2.91) and days readmitted (rate ratio = 3.97; 95% CI, 3.11-5.08) after adjustment for demographics, comorbidities, and medications. Conclusion: Recurrent CDI patients are significantly more likely than patients without a recurrence to be readmitted and spend increased time readmitted to the hospital.
KW - Clostridium difficile
KW - Cohort
KW - Epidemiology
KW - Readmission
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=84933280363&partnerID=8YFLogxK
U2 - 10.1016/j.ajic.2014.12.020
DO - 10.1016/j.ajic.2014.12.020
M3 - Article
C2 - 25690876
AN - SCOPUS:84933280363
SN - 0196-6553
VL - 43
SP - 318
EP - 322
JO - American Journal of Infection Control
JF - American Journal of Infection Control
IS - 4
ER -