Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseases

S. Kendall Smith, Erik S. Musiek

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


The 24-h rotational period of the earth has driven evolution of biological systems that serve to synchronize organismal physiology and behavior to this predictable environmental event. In mammals, the circadian (circa, “about” and dia, “a day”) clock keeps 24-h time at the organismal and cellular level, optimizing biological function for a given time of day. The most obvious circadian output is the sleep-wake cycle, though countless bodily functions, ranging from hormone levels to cognitive function, are influenced by the circadian clock. Here we discuss the regulation of metabolic pathways by the circadian clock, discuss the evidence implicating circadian and sleep disruption in neurodegenerative diseases, and suggest some possible connections between the clock, metabolism, and neurodegenerative disease.

Original languageEnglish
Title of host publicationMetabolic and Bioenergetic Drivers of Neurodegenerative Disease
Subtitle of host publicationNeurodegenerative Disease Research and Commonalities with Metabolic Diseases
EditorsGrażyna Söderbom, Russell Esterline, Jan Oscarsson, Mark P. Mattson
PublisherAcademic Press Inc.
Number of pages20
ISBN (Print)9780128200766
StatePublished - 2020

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514


  • Alzheimer's disease (AD)
  • Circadian rhythms
  • Clocks
  • Huntington's disease (HD)
  • Metabolism
  • Mitochondria
  • NAD
  • Neurodegeneration
  • Parkinson's disease (PD)
  • Sirtuins
  • Sleep disorders
  • Suprachiasmatic nucleus (SCN)


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