Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

S. Todd Callahan; Mark Wolff; Heather R. Hill; Kathryn M. Edwards; Wendy Keitel; Robert Atmar; Shital Patel; Hana El Sahly; Flor Munoz; W. Paul Glezen; Rebecca Brady; Robert Frenck; David Bernstein; Christopher Harrison; Mary Anne Jackson; Douglas Swanson; Jason Newland; Angela Myers; Robyn A. Livingston; Emmanuel Walter; Rowena Dolor; Kenneth Schmader; Mark J. Mulligan; Srilatha Edupuganti; Nadine Rouphael; Jennifer Whitaker; Paul Spearman; Harry Keyserling; Andi Shane; Allison Ross Eckard; Lisa A. Jackson; Sharon E. Frey; Robert B. Belshe; Irene Graham; Edwin Anderson; Janet A. Englund; Sara Healy; Patricia Winokur; Jack Stapleton; Jeffrey Meier; Karen Kotloff; Wilbur Chen; Julia Hutter; Ina Stephens; Susan Wooten; Anna Wald

doi:10.1093/infdis/jiu245

Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

S. Todd Callahan
, Mark Wolff
, Heather R. Hill
, Kathryn M. Edwards
, Wendy Keitel
, Robert Atmar
, Shital Patel
, Hana El Sahly
, Flor Munoz
, W. Paul Glezen
, Rebecca Brady
, Robert Frenck
, David Bernstein
, Christopher Harrison
, Mary Anne Jackson
, Douglas Swanson
, Jason Newland
, Angela Myers
, Robyn A. Livingston
, Emmanuel Walter

Rowena Dolor, Kenneth Schmader, Mark J. Mulligan, Srilatha Edupuganti, Nadine Rouphael, Jennifer Whitaker, Paul Spearman, Harry Keyserling, Andi Shane, Allison Ross Eckard, Lisa A. Jackson, Sharon E. Frey, Robert B. Belshe, Irene Graham, Edwin Anderson, Janet A. Englund, Sara Healy, Patricia Winokur, Jack Stapleton, Jeffrey Meier, Karen Kotloff, Wilbur Chen, Julia Hutter, Ina Stephens, Susan Wooten, Anna Wald

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

Original language	English
Pages (from-to)	1270-1274
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	210
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiu245
State	Published - Oct 15 2014

Keywords

Body mass index
Immune response
Influenza vaccine
Obesity

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10.1093/infdis/jiu245

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Callahan, S. T., Wolff, M., Hill, H. R., Edwards, K. M., Keitel, W., Atmar, R., Patel, S., El Sahly, H., Munoz, F., Glezen, W. P., Brady, R., Frenck, R., Bernstein, D., Harrison, C., Jackson, M. A., Swanson, D., Newland, J., Myers, A., Livingston, R. A., ... Wald, A. (2014). Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults. Journal of Infectious Diseases, 210(8), 1270-1274. https://doi.org/10.1093/infdis/jiu245

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title = "Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults",

abstract = "Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.",

keywords = "Body mass index, Immune response, Influenza vaccine, Obesity",

author = "Callahan, \{S. Todd\} and Mark Wolff and Hill, \{Heather R.\} and Edwards, \{Kathryn M.\} and Wendy Keitel and Robert Atmar and Shital Patel and \{El Sahly\}, Hana and Flor Munoz and Glezen, \{W. Paul\} and Rebecca Brady and Robert Frenck and David Bernstein and Christopher Harrison and Jackson, \{Mary Anne\} and Douglas Swanson and Jason Newland and Angela Myers and Livingston, \{Robyn A.\} and Emmanuel Walter and Rowena Dolor and Kenneth Schmader and Mulligan, \{Mark J.\} and Srilatha Edupuganti and Nadine Rouphael and Jennifer Whitaker and Paul Spearman and Harry Keyserling and Andi Shane and Eckard, \{Allison Ross\} and Jackson, \{Lisa A.\} and Frey, \{Sharon E.\} and Belshe, \{Robert B.\} and Irene Graham and Edwin Anderson and Englund, \{Janet A.\} and Sara Healy and Patricia Winokur and Jack Stapleton and Jeffrey Meier and Karen Kotloff and Wilbur Chen and Julia Hutter and Ina Stephens and Susan Wooten and Anna Wald",

note = "Publisher Copyright: {\textcopyright} The Author 2014.",

year = "2014",

month = oct,

day = "15",

doi = "10.1093/infdis/jiu245",

language = "English",

volume = "210",

pages = "1270--1274",

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Callahan, ST, Wolff, M, Hill, HR, Edwards, KM, Keitel, W, Atmar, R, Patel, S, El Sahly, H, Munoz, F, Glezen, WP, Brady, R, Frenck, R, Bernstein, D, Harrison, C, Jackson, MA, Swanson, D, Newland, J, Myers, A, Livingston, RA, Walter, E, Dolor, R, Schmader, K, Mulligan, MJ, Edupuganti, S, Rouphael, N, Whitaker, J, Spearman, P, Keyserling, H, Shane, A, Eckard, AR, Jackson, LA, Frey, SE, Belshe, RB, Graham, I, Anderson, E, Englund, JA, Healy, S, Winokur, P, Stapleton, J, Meier, J, Kotloff, K, Chen, W, Hutter, J, Stephens, I, Wooten, S & Wald, A 2014, 'Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults', Journal of Infectious Diseases, vol. 210, no. 8, pp. 1270-1274. https://doi.org/10.1093/infdis/jiu245

TY - JOUR

T1 - Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

AU - Callahan, S. Todd

AU - Wolff, Mark

AU - Hill, Heather R.

AU - Edwards, Kathryn M.

AU - Keitel, Wendy

AU - Atmar, Robert

AU - Patel, Shital

AU - El Sahly, Hana

AU - Munoz, Flor

AU - Glezen, W. Paul

AU - Brady, Rebecca

AU - Frenck, Robert

AU - Bernstein, David

AU - Harrison, Christopher

AU - Jackson, Mary Anne

AU - Swanson, Douglas

AU - Newland, Jason

AU - Myers, Angela

AU - Livingston, Robyn A.

AU - Walter, Emmanuel

AU - Dolor, Rowena

AU - Schmader, Kenneth

AU - Mulligan, Mark J.

AU - Edupuganti, Srilatha

AU - Rouphael, Nadine

AU - Whitaker, Jennifer

AU - Spearman, Paul

AU - Keyserling, Harry

AU - Shane, Andi

AU - Eckard, Allison Ross

AU - Jackson, Lisa A.

AU - Frey, Sharon E.

AU - Belshe, Robert B.

AU - Graham, Irene

AU - Anderson, Edwin

AU - Englund, Janet A.

AU - Healy, Sara

AU - Winokur, Patricia

AU - Stapleton, Jack

AU - Meier, Jeffrey

AU - Kotloff, Karen

AU - Chen, Wilbur

AU - Hutter, Julia

AU - Stephens, Ina

AU - Wooten, Susan

AU - Wald, Anna

PY - 2014/10/15

Y1 - 2014/10/15

N2 - Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

AB - Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

KW - Body mass index

KW - Immune response

KW - Influenza vaccine

KW - Obesity

UR - https://www.scopus.com/pages/publications/84911001339

U2 - 10.1093/infdis/jiu245

DO - 10.1093/infdis/jiu245

M3 - Article

C2 - 24795475

AN - SCOPUS:84911001339

SN - 0022-1899

VL - 210

SP - 1270

EP - 1274

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults

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