Impact of antibiotic policy on antibiotic consumption in a neonatal intensive care unit in India

Dasaratha Ramaiah Jinka, Sumanth Gandra, Gerardo Alvarez-Uria, Nuria Torre, Durgesh Tadepalli, Raghu Prakash Reddy Nayakanti

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU). Methods: This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis. Results: There was no significant change (12.47 vs. 11.47 DDD/100 patient-days; P = 0.57) in overall antibiotic consumption. A significant increase in the proportion of patients on first-line agents (ampicillin and gentamicin) (66% (n=449) vs. 84% (n=491); P <0.001) and significant decrease in consumption of third generation cephalosporins (1.45 vs. 0.45 DDD/100 patient-days; P =0.002) was observed. Conclusion: Antibiotic policy increased the use of first-line agents and decreased the consumption of third generation cephalosporins.

Original languageEnglish
Pages (from-to)739-741
Number of pages3
JournalIndian pediatrics
Volume54
Issue number9
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Keywords

  • Antibiotic resistance
  • Infection control
  • Rational prescription

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