TY - JOUR
T1 - Impact of antibiotic policy on antibiotic consumption in a neonatal intensive care unit in India
AU - Jinka, Dasaratha Ramaiah
AU - Gandra, Sumanth
AU - Alvarez-Uria, Gerardo
AU - Torre, Nuria
AU - Tadepalli, Durgesh
AU - Nayakanti, Raghu Prakash Reddy
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Objective: To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU). Methods: This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis. Results: There was no significant change (12.47 vs. 11.47 DDD/100 patient-days; P = 0.57) in overall antibiotic consumption. A significant increase in the proportion of patients on first-line agents (ampicillin and gentamicin) (66% (n=449) vs. 84% (n=491); P <0.001) and significant decrease in consumption of third generation cephalosporins (1.45 vs. 0.45 DDD/100 patient-days; P =0.002) was observed. Conclusion: Antibiotic policy increased the use of first-line agents and decreased the consumption of third generation cephalosporins.
AB - Objective: To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU). Methods: This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis. Results: There was no significant change (12.47 vs. 11.47 DDD/100 patient-days; P = 0.57) in overall antibiotic consumption. A significant increase in the proportion of patients on first-line agents (ampicillin and gentamicin) (66% (n=449) vs. 84% (n=491); P <0.001) and significant decrease in consumption of third generation cephalosporins (1.45 vs. 0.45 DDD/100 patient-days; P =0.002) was observed. Conclusion: Antibiotic policy increased the use of first-line agents and decreased the consumption of third generation cephalosporins.
KW - Antibiotic resistance
KW - Infection control
KW - Rational prescription
UR - http://www.scopus.com/inward/record.url?scp=85039561767&partnerID=8YFLogxK
U2 - 10.1007/s13312-017-1165-4
DO - 10.1007/s13312-017-1165-4
M3 - Article
C2 - 28984251
AN - SCOPUS:85039561767
SN - 0019-6061
VL - 54
SP - 739
EP - 741
JO - Indian Pediatrics
JF - Indian Pediatrics
IS - 9
ER -