Immunotherapy in Lung Cancer

Lingling Du, Roy S. Herbst, Daniel Morgensztern

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The treatment of patients with good performance status and advanced stage non–small cell lung cancer has been based on the use of first-line platinum-based doublet and second-line docetaxel. Immunotherapy represents a new therapeutic approach with the potential for prolonged benefit. Although the vaccines studied have not shown benefit in patients with non–small cell lung cancer, immune checkpoint inhibitors against the PD-1/PD-L1 axis showed increased overall survival compared with docetaxel in randomized clinical trials, which led to the approval of nivolumab and pembrolizumab. Because only a minority of patients benefit from this class of drugs, there has been an intense search for biomarkers.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalHematology/Oncology Clinics of North America
Volume31
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Immune checkpoint inhibitors
  • Non–small cell lung cancer
  • PD-L1
  • Vaccines

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