TY - JOUR
T1 - Immunosuppressants and risk of Parkinson disease
AU - Racette, Brad A.
AU - Gross, Anat
AU - Vouri, Scott Martin
AU - Camacho-Soto, Alejandra
AU - Willis, Allison W.
AU - Searles Nielsen, Susan
N1 - Publisher Copyright:
© 2018 Washington University. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
PY - 2018/7
Y1 - 2018/7
N2 - We performed a population-based case–control study of United States Medicare beneficiaries age 60–90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use of immunosuppressants. Inosine monophosphate dehydrogenase inhibitors (relative risk = 0.64; 95% confidence interval 0.51–0.79) and corticosteroids (relative risk = 0.80; 95% confidence interval 0.77–0.83) were both associated with a lower risk of Parkinson disease. Inverse associations for both remained after applying a 12-month exposure lag. Overall, this study provides evidence that use of corticosteroids and inosine monophosphate dehydrogenase inhibitors might lower the risk of Parkinson disease.
AB - We performed a population-based case–control study of United States Medicare beneficiaries age 60–90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use of immunosuppressants. Inosine monophosphate dehydrogenase inhibitors (relative risk = 0.64; 95% confidence interval 0.51–0.79) and corticosteroids (relative risk = 0.80; 95% confidence interval 0.77–0.83) were both associated with a lower risk of Parkinson disease. Inverse associations for both remained after applying a 12-month exposure lag. Overall, this study provides evidence that use of corticosteroids and inosine monophosphate dehydrogenase inhibitors might lower the risk of Parkinson disease.
UR - http://www.scopus.com/inward/record.url?scp=85047841129&partnerID=8YFLogxK
U2 - 10.1002/acn3.580
DO - 10.1002/acn3.580
M3 - Article
C2 - 30009205
AN - SCOPUS:85047841129
SN - 2328-9503
VL - 5
SP - 870
EP - 875
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 7
ER -