Immunomorphological characteristics of pleomorphic adenoma of salivary glands.

A. Angelov, K. Dikranian, M. Trosheva

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The immunohistochemical profile of 23 pleomorphic adenomas and 7 normal salivary glands was studied. We used antisera to vimentin (V), desmin (D), epithelial membrane antigen (EMA), prostate specific antigen (PSA), pancytokeratin, carcinoembryonic antigen (CEA), glial fibrillary acidic protein (GFAP) and S-100 protein. In the ducts and myoepithelial cells of normal salivary glands immunopositivity to most of the cytoskeletal proteins, EMA and CEA was observed. GFAP was localized only in cells of striated ducts. Major differences in the expression of various antigens among tubular structures, solid sheets, the myxoid and chondroid in the pleomorphic adenoma were encountered. Appearance of GFAP as a sign of stromal transformation into myxoid and chondroid was detected. Judging from these comparative immunohistochemical characteristics between normal salivary glands and pleomorphic adenomas, we assume that tumour cells originate from the reserve cells of intercalated and striated ducts.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalBulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie
Volume39
Issue number3-4
StatePublished - Jun 1 1996

Fingerprint

Dive into the research topics of 'Immunomorphological characteristics of pleomorphic adenoma of salivary glands.'. Together they form a unique fingerprint.

Cite this