Immunolymphoscintigraphy in breast cancer: Evaluation using 131I- labeled monoclonal antibody B72.3

Lorraine M. Fig; Raya S. Brown; Lisa Von Moll; Henry D. Appelman; Ralph Stevens; Jay Harness; David August; Vernon K. Sondak; Alfred E. Chang; Kenneth R. Zasadny; Susan J. Fisher; Jon W. Johnson; Max S. Wicha; David Colcher; Allen S. Lichter; Richard L. Wahl

doi:10.1016/S0969-8051(97)00172-8

Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3

Lorraine M. Fig
, Raya S. Brown
, Lisa Von Moll
, Henry D. Appelman
, Ralph Stevens
, Jay Harness
, David August
, Vernon K. Sondak
, Alfred E. Chang
, Kenneth R. Zasadny
, Susan J. Fisher
, Jon W. Johnson
, Max S. Wicha
, David Colcher
, Allen S. Lichter
, Richard L. Wahl

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Noninvasive axillary lymph node staging was investigated using [¹³¹I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [¹³¹I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [¹³¹I]B72.3 is unsuitable to discriminate axillary node tumor involvement.

Original language	English
Pages (from-to)	251-260
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/S0969-8051(97)00172-8
State	Published - Apr 1998

Keywords

Breast neoplasm
Iodine radioisotopes
Lymphatic metastasis
Monoclonal antibodies
Radionuclide imaging

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10.1016/S0969-8051(97)00172-8

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Fig, L. M., Brown, R. S., Von Moll, L., Appelman, H. D., Stevens, R., Harness, J., August, D., Sondak, V. K., Chang, A. E., Zasadny, K. R., Fisher, S. J., Johnson, J. W., Wicha, M. S., Colcher, D., Lichter, A. S., & Wahl, R. L. (1998). Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3. Nuclear Medicine and Biology, 25(3), 251-260. https://doi.org/10.1016/S0969-8051(97)00172-8

@article{9ef81625f14142e9b5353b5d31378c14,

title = "Immunolymphoscintigraphy in breast cancer: Evaluation using 131I- labeled monoclonal antibody B72.3",

abstract = "Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (\%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.",

keywords = "Breast neoplasm, Iodine radioisotopes, Lymphatic metastasis, Monoclonal antibodies, Radionuclide imaging",

author = "Fig, \{Lorraine M.\} and Brown, \{Raya S.\} and \{Von Moll\}, Lisa and Appelman, \{Henry D.\} and Ralph Stevens and Jay Harness and David August and Sondak, \{Vernon K.\} and Chang, \{Alfred E.\} and Zasadny, \{Kenneth R.\} and Fisher, \{Susan J.\} and Johnson, \{Jon W.\} and Wicha, \{Max S.\} and David Colcher and Lichter, \{Allen S.\} and Wahl, \{Richard L.\}",

note = "Funding Information: Financial support for this work was provided by grant PO-1 CA42768, awarded to R. L. W. by the National Cancer Institute.",

year = "1998",

month = apr,

doi = "10.1016/S0969-8051(97)00172-8",

language = "English",

volume = "25",

pages = "251--260",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

number = "3",

}

Fig, LM, Brown, RS, Von Moll, L, Appelman, HD, Stevens, R, Harness, J, August, D, Sondak, VK, Chang, AE, Zasadny, KR, Fisher, SJ, Johnson, JW, Wicha, MS, Colcher, D, Lichter, AS & Wahl, RL 1998, 'Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3', Nuclear Medicine and Biology, vol. 25, no. 3, pp. 251-260. https://doi.org/10.1016/S0969-8051(97)00172-8

TY - JOUR

T1 - Immunolymphoscintigraphy in breast cancer

T2 - Evaluation using 131I- labeled monoclonal antibody B72.3

AU - Fig, Lorraine M.

AU - Brown, Raya S.

AU - Von Moll, Lisa

AU - Appelman, Henry D.

AU - Stevens, Ralph

AU - Harness, Jay

AU - August, David

AU - Sondak, Vernon K.

AU - Chang, Alfred E.

AU - Zasadny, Kenneth R.

AU - Fisher, Susan J.

AU - Johnson, Jon W.

AU - Wicha, Max S.

AU - Colcher, David

AU - Lichter, Allen S.

AU - Wahl, Richard L.

N1 - Funding Information: Financial support for this work was provided by grant PO-1 CA42768, awarded to R. L. W. by the National Cancer Institute.

PY - 1998/4

Y1 - 1998/4

N2 - Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.

AB - Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and γ-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.

KW - Breast neoplasm

KW - Iodine radioisotopes

KW - Lymphatic metastasis

KW - Monoclonal antibodies

KW - Radionuclide imaging

UR - https://www.scopus.com/pages/publications/0032054149

U2 - 10.1016/S0969-8051(97)00172-8

DO - 10.1016/S0969-8051(97)00172-8

M3 - Article

C2 - 9620631

AN - SCOPUS:0032054149

SN - 0969-8051

VL - 25

SP - 251

EP - 260

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 3

ER -

Immunolymphoscintigraphy in breast cancer: Evaluation using ¹³¹I- labeled monoclonal antibody B72.3

Abstract

Keywords

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