@inbook{7c8ac52fa12b44a585ec82731fc9c22f,
title = "Immunology of Cytokine Storm Syndromes: Natural Killer Cells",
abstract = "Natural killer (NK) cells are innate immune lymphocytes that rapidly produce cytokines upon activation and kill target cells. NK cells have been of particular interest in primary hemophagocytic lymphohistiocytosis (pHLH) since all of the genetic defects associated with this disorder cause diminished cytotoxic capacity of NK cells and T lymphocytes, and assays of NK cell killing are used clinically for the diagnosis of HLH. Herein, we review human NK cell biology and the significance of alterations in NK cell function in the diagnosis and pathogenesis of HLH.",
keywords = "Cytotoxicity, Granzyme, Interferon gamma, Interleukins, Natural killer cell, Perforin",
author = "French, {Anthony R.} and Cron, {Randy Q.} and Cooper, {Megan A.}",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.",
year = "2024",
doi = "10.1007/978-3-031-59815-9_11",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "145--159",
booktitle = "Advances in Experimental Medicine and Biology",
}