Immunology of age-related macular degeneration

Jayakrishna Ambati; John P. Atkinson; Bradley D. Gelfand

doi:10.1038/nri3459

Immunology of age-related macular degeneration

Jayakrishna Ambati
, John P. Atkinson
, Bradley D. Gelfand

Research output: Contribution to journal › Review article › peer-review

566 Scopus citations

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

Original language	English
Pages (from-to)	438-451
Number of pages	14
Journal	Nature Reviews Immunology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1038/nri3459
State	Published - Jun 2013

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10.1038/nri3459

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@article{6786d10e221d464598edf78e98df5cbf,

title = "Immunology of age-related macular degeneration",

abstract = "Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.",

author = "Jayakrishna Ambati and Atkinson, \{John P.\} and Gelfand, \{Bradley D.\}",

note = "Funding Information: J.A. is supported by US National Institutes of Health (NIH) grants (R01EY018836, R01EY020672 and R01EY022238), the Doris Duke Charitable Foundation, USA, the Ellison Medical Foundation, USA, the Burroughs Wellcome Fund, USA, the Reeves Foundation, USA, a Dr. E. Vernon Smith and Eloise C. Smith Endowment and a Research to Prevent Blindness Unrestricted Grant, USA. J.P.A. is supported by NIH grants (AI041592, AR007279, AR0483335, GM099111 and HL112303), the Edward N. and Della L. Thome Memorial Foundation, USA, and Alexion Pharmaceuticals, USA. B.D.G. is suported by the National Center for Advancing Translational Sciences, USA, grants UL1TR000117 and UL1TR000117. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.",

year = "2013",

month = jun,

doi = "10.1038/nri3459",

language = "English",

volume = "13",

pages = "438--451",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

number = "6",

}

TY - JOUR

T1 - Immunology of age-related macular degeneration

AU - Ambati, Jayakrishna

AU - Atkinson, John P.

AU - Gelfand, Bradley D.

N1 - Funding Information: J.A. is supported by US National Institutes of Health (NIH) grants (R01EY018836, R01EY020672 and R01EY022238), the Doris Duke Charitable Foundation, USA, the Ellison Medical Foundation, USA, the Burroughs Wellcome Fund, USA, the Reeves Foundation, USA, a Dr. E. Vernon Smith and Eloise C. Smith Endowment and a Research to Prevent Blindness Unrestricted Grant, USA. J.P.A. is supported by NIH grants (AI041592, AR007279, AR0483335, GM099111 and HL112303), the Edward N. and Della L. Thome Memorial Foundation, USA, and Alexion Pharmaceuticals, USA. B.D.G. is suported by the National Center for Advancing Translational Sciences, USA, grants UL1TR000117 and UL1TR000117. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

PY - 2013/6

Y1 - 2013/6

N2 - Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

AB - Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

UR - https://www.scopus.com/pages/publications/84878214672

U2 - 10.1038/nri3459

DO - 10.1038/nri3459

M3 - Review article

C2 - 23702979

AN - SCOPUS:84878214672

SN - 1474-1733

VL - 13

SP - 438

EP - 451

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 6

ER -

Immunology of age-related macular degeneration

Abstract

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