@article{6786d10e221d464598edf78e98df5cbf,
title = "Immunology of age-related macular degeneration",
abstract = "Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.",
author = "Jayakrishna Ambati and Atkinson, {John P.} and Gelfand, {Bradley D.}",
note = "Funding Information: J.A. is supported by US National Institutes of Health (NIH) grants (R01EY018836, R01EY020672 and R01EY022238), the Doris Duke Charitable Foundation, USA, the Ellison Medical Foundation, USA, the Burroughs Wellcome Fund, USA, the Reeves Foundation, USA, a Dr. E. Vernon Smith and Eloise C. Smith Endowment and a Research to Prevent Blindness Unrestricted Grant, USA. J.P.A. is supported by NIH grants (AI041592, AR007279, AR0483335, GM099111 and HL112303), the Edward N. and Della L. Thome Memorial Foundation, USA, and Alexion Pharmaceuticals, USA. B.D.G. is suported by the National Center for Advancing Translational Sciences, USA, grants UL1TR000117 and UL1TR000117. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.",
year = "2013",
month = jun,
doi = "10.1038/nri3459",
language = "English",
volume = "13",
pages = "438--451",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
number = "6",
}