@article{a1ab2780b17e4e6dbc4da48a862d6eff,
title = "Immunology and the elusive AIDS vaccine",
abstract = "Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this goal is achievable. Natural immunity is not protective, and despite immunogenicity of HIV vaccine candidates, human trials have exclusively yielded disappointing results. Nevertheless, there is an indication that success may be possible, but this will be dependent on understanding the antiviral immune response in unprecedented depth to identify and engineer the types of immunity required. Here we outline fundamental immunological questions that need to be answered to develop a protective HIV vaccine, and the immediate need to harness a much broader scientific community to achieve this goal.",
author = "Virgin, {Herbert W.} and Walker, {Bruce D.}",
note = "Funding Information: Acknowledgements We would like to acknowledge, while accepting full responsibility for the content and opinions expressed, open discussions and correspondence with: M. Altfeld, D. Brooks, D. Burton, M. Colonna, L. Corey, B. Beutler, D. Barouch, A. Chakraborty, F. Chisari, R. Desrosiers, M. Diamond, A. Garcia-Sastre, L. Glimcher, P. Goulder, H. Greenberg, A. Haase, K. Hasenkrug, B. Haynes, M. Hirsch, S. Abdool-Karim, W. Koff, B. Lamb, J. Lifson, J. Loh, R. Medzhitov, J. Moore, M. Nussenzweig, M. Oldstone, L. Picker, B. Roizman, R. Siliciano, G. Silvestri, S. Wain-Hobson, D. Watkins, R. Weiss, J. Wherry and O. Yang. This work was supported by grants from the National Institutes of Health (H.W.V. and B.D.W.), the Bill and Melinda Gates Foundation (B.D.W.), and a gift from the Mark and Lisa Schwartz Foundation (B.D.W.).",
year = "2010",
month = mar,
day = "11",
doi = "10.1038/nature08898",
language = "English",
volume = "464",
pages = "224--231",
journal = "Nature",
issn = "0028-0836",
number = "7286",
}