TY - JOUR
T1 - Immunological headgear
T2 - antiviral immune responses protect against neuroinvasive West Nile virus
AU - Klein, Robyn S.
AU - Diamond, Michael S.
N1 - Funding Information:
This work was supported by National Institute of Health/National Institute of Neurologic Disorders and Stroke grants NS045607 and NS052632 and by a grant from the Midwest Regional Center for Excellence in Emerging Infectious Diseases.
PY - 2008/7
Y1 - 2008/7
N2 - With the emergence of epidemic strains of West Nile virus (WNV) in North America, there has been a surge in new research and knowledge regarding the peripheral immune responses that prevent neuroinvasion, the routes of WNV entry into the central nervous system (CNS) and the critical CNS immune responses that promote viral clearance and recovery at this anatomic site. WNV infection induces archetypal antiviral immune responses that, in most cases, lead to elimination of the virus with relatively few immunopathological consequences. Here, we present our current understanding of the innate and adaptive immune responses that limit dissemination to the CNS from WNV infection and the antiviral immune responses within the CNS that intervene when they fail.
AB - With the emergence of epidemic strains of West Nile virus (WNV) in North America, there has been a surge in new research and knowledge regarding the peripheral immune responses that prevent neuroinvasion, the routes of WNV entry into the central nervous system (CNS) and the critical CNS immune responses that promote viral clearance and recovery at this anatomic site. WNV infection induces archetypal antiviral immune responses that, in most cases, lead to elimination of the virus with relatively few immunopathological consequences. Here, we present our current understanding of the innate and adaptive immune responses that limit dissemination to the CNS from WNV infection and the antiviral immune responses within the CNS that intervene when they fail.
UR - http://www.scopus.com/inward/record.url?scp=46049095465&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2008.05.004
DO - 10.1016/j.molmed.2008.05.004
M3 - Review article
C2 - 18539532
AN - SCOPUS:46049095465
SN - 1471-4914
VL - 14
SP - 286
EP - 294
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 7
ER -