Immunologic mapping of glycomes: Implications for cancer diagnosis and therapy

Dapeng Zhou; Steven B. Levery; Fong Fu Hsu; Peng G. Wang; Susann Teneberg; Igor C. Almeida; Yunsen Li; Huaxi Xu; Lai Xi Wang; Chengfeng Xia; Nuhad K. Ibrahim; Katja Michael

doi:10.2741/s242

Immunologic mapping of glycomes: Implications for cancer diagnosis and therapy

Dapeng Zhou, Steven B. Levery, Fong Fu Hsu, Peng G. Wang, Susann Teneberg, Igor C. Almeida, Yunsen Li, Huaxi Xu, Lai Xi Wang, Chengfeng Xia, Nuhad K. Ibrahim, Katja Michael

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4 Scopus citations

Abstract

Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

Original language	English
Pages (from-to)	1520-1532
Number of pages	13
Journal	Frontiers in Bioscience - Scholar
Volume	3 S
Issue number	4
DOIs	https://doi.org/10.2741/s242
State	Published - Jun 1 2011

Keywords

Cancer
Glycomics
Immunopathogenesis
Immunotherapy
Mass spectrometry
Review

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title = "Immunologic mapping of glycomes: Implications for cancer diagnosis and therapy",

abstract = "Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the {"}immunologic mapping{"} of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.",

keywords = "Cancer, Glycomics, Immunopathogenesis, Immunotherapy, Mass spectrometry, Review",

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T1 - Immunologic mapping of glycomes

T2 - Implications for cancer diagnosis and therapy

AU - Zhou, Dapeng

AU - Levery, Steven B.

AU - Hsu, Fong Fu

AU - Wang, Peng G.

AU - Teneberg, Susann

AU - Almeida, Igor C.

AU - Li, Yunsen

AU - Xu, Huaxi

AU - Wang, Lai Xi

AU - Xia, Chengfeng

AU - Ibrahim, Nuhad K.

AU - Michael, Katja

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

AB - Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

KW - Cancer

KW - Glycomics

KW - Immunopathogenesis

KW - Immunotherapy

KW - Mass spectrometry

KW - Review

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Immunologic mapping of glycomes: Implications for cancer diagnosis and therapy

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