Immunologic mapping of glycomes: Implications for cancer diagnosis and therapy

Dapeng Zhou, Steven B. Levery, Fong Fu Hsu, Peng G. Wang, Susann Teneberg, Igor C. Almeida, Yunsen Li, Huaxi Xu, Lai Xi Wang, Chengfeng Xia, Nuhad K. Ibrahim, Katja Michael

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

Original languageEnglish
Pages (from-to)1520-1532
Number of pages13
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number4
StatePublished - Jun 1 2011


  • Cancer
  • Glycomics
  • Immunopathogenesis
  • Immunotherapy
  • Mass spectrometry
  • Review


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