Immunologic events in experimental hypersensitivity granulomas

E. R. Unanue, B. Benacerraf

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Polyacrylamide beads were covalently linked to proteins and injected intravenously into normal or immune guinea pigs. The beads trapped in the lung produced very mild foreign body granulomas in nonimmune guinea pigs. In immune guinea pigs, severe granulomas developed which progressed through the several characteristic histologic stages with time. Severe granulomatous reactions developed only upon recognition of carrier determinants of hapten protein conjugates; thus guinea pigs immune to dinitrophenyl hapten (DNP) hemocyanin developed characteristic granulomas only upon injection of beads coated with hemocyanin or DNP hemocyanin, but not with DNP on another unrelated antigen. Granulomatous reactivity was passively transferred into normal animals by lymph node cells but not by serum antibody from sensitized guinea pigs.

Original languageEnglish
Pages (from-to)349-364
Number of pages16
JournalAmerican Journal of Pathology
Volume71
Issue number3
StatePublished - Dec 1 1973
Externally publishedYes

Fingerprint Dive into the research topics of 'Immunologic events in experimental hypersensitivity granulomas'. Together they form a unique fingerprint.

  • Cite this