Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia

Robert E. Schmidt; Denise A. Dorsey; Kevin A. Roth

doi:10.1016/S0006-8993(10)80043-5

Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia

Robert E. Schmidt
, Denise A. Dorsey
, Kevin A. Roth

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

To compare the neuropeptide specificity of dystrophic axon formation in aging versus diabetic human sympathetic ganglia we have immunohisto-chemically characterized neuropeptide Y (NPY) and substance P containing intraganglionic nerve terminals. Prevertebral superior mesenteric but not paravertebral superior cervical ganglia developed markedly swollen NPY containing axonal termini with both aging and diabetes. Substance P containing nerve terminals failed to develop dystrophic changes. Selective loss of classes of nerve terminals may result in discrete functional sequellae.

Original language	English
Pages (from-to)	320-326
Number of pages	7
Journal	Brain Research
Volume	583
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(10)80043-5
State	Published - 1992

Keywords

Aging
Diabetes
Neuroaxonal dystrophy
Neuropeptide Y
Sympathetic autonomic neuropathy

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10.1016/S0006-8993(10)80043-5

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title = "Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia",

abstract = "To compare the neuropeptide specificity of dystrophic axon formation in aging versus diabetic human sympathetic ganglia we have immunohisto-chemically characterized neuropeptide Y (NPY) and substance P containing intraganglionic nerve terminals. Prevertebral superior mesenteric but not paravertebral superior cervical ganglia developed markedly swollen NPY containing axonal termini with both aging and diabetes. Substance P containing nerve terminals failed to develop dystrophic changes. Selective loss of classes of nerve terminals may result in discrete functional sequellae.",

keywords = "Aging, Diabetes, Neuroaxonal dystrophy, Neuropeptide Y, Sympathetic autonomic neuropathy",

author = "Schmidt, \{Robert E.\} and Dorsey, \{Denise A.\} and Roth, \{Kevin A.\}",

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journal = "Brain Research",

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T1 - Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia

AU - Schmidt, Robert E.

AU - Dorsey, Denise A.

AU - Roth, Kevin A.

PY - 1992

Y1 - 1992

N2 - To compare the neuropeptide specificity of dystrophic axon formation in aging versus diabetic human sympathetic ganglia we have immunohisto-chemically characterized neuropeptide Y (NPY) and substance P containing intraganglionic nerve terminals. Prevertebral superior mesenteric but not paravertebral superior cervical ganglia developed markedly swollen NPY containing axonal termini with both aging and diabetes. Substance P containing nerve terminals failed to develop dystrophic changes. Selective loss of classes of nerve terminals may result in discrete functional sequellae.

AB - To compare the neuropeptide specificity of dystrophic axon formation in aging versus diabetic human sympathetic ganglia we have immunohisto-chemically characterized neuropeptide Y (NPY) and substance P containing intraganglionic nerve terminals. Prevertebral superior mesenteric but not paravertebral superior cervical ganglia developed markedly swollen NPY containing axonal termini with both aging and diabetes. Substance P containing nerve terminals failed to develop dystrophic changes. Selective loss of classes of nerve terminals may result in discrete functional sequellae.

KW - Aging

KW - Diabetes

KW - Neuroaxonal dystrophy

KW - Neuropeptide Y

KW - Sympathetic autonomic neuropathy

UR - https://www.scopus.com/pages/publications/0026766031

U2 - 10.1016/S0006-8993(10)80043-5

DO - 10.1016/S0006-8993(10)80043-5

M3 - Article

C2 - 1380399

AN - SCOPUS:0026766031

SN - 0006-8993

VL - 583

SP - 320

EP - 326

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia

Abstract

Keywords

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