Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia

Robert E. Schmidt, Denise A. Dorsey, Kevin A. Roth

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

To compare the neuropeptide specificity of dystrophic axon formation in aging versus diabetic human sympathetic ganglia we have immunohisto-chemically characterized neuropeptide Y (NPY) and substance P containing intraganglionic nerve terminals. Prevertebral superior mesenteric but not paravertebral superior cervical ganglia developed markedly swollen NPY containing axonal termini with both aging and diabetes. Substance P containing nerve terminals failed to develop dystrophic changes. Selective loss of classes of nerve terminals may result in discrete functional sequellae.

Original languageEnglish
Pages (from-to)320-326
Number of pages7
JournalBrain Research
Volume583
Issue number1-2
DOIs
StatePublished - Jan 1 1992

Keywords

  • Aging
  • Diabetes
  • Neuroaxonal dystrophy
  • Neuropeptide Y
  • Sympathetic autonomic neuropathy

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