Immunodeficiency-disease-associated atypical chronic hepatitis: A clinicopathologic study

Dale C. Snover, A. H. Filipovich, Louis P. Dehner

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Chronic hepatitis occurring in patients with primary immunodeficiency disease is an uncommonly reported phenomenon. This study describes our experience with 3 patients with various immunologic abnormalities who developed chronic atypical lymphocytic infiltrates in the liver. There was a temporal relationship to Epstein-Barr Virus infection in 2 cases and hepatitis A in 1. In view of the increased incidence of malignant lymphoma in several of the primary immunodeficiency states, these cases present a difficult diagnostic challenge. The recognition of the association of infiltration of the liver with small cleaved lymphocytes and a viral infection in an immunodeficient patient should alert the pathologist to the possibility that the infiltrate does not represent malignant lymphoma. These cases may be analogous to similar virus-associated lymphoproliferative disorders described in the acquired immunodeficiency of renal transplantation..

Original languageEnglish
Pages (from-to)229-241
Number of pages13
JournalFetal and Pediatric Pathology
Issue number2
StatePublished - 1983


  • Atypical lymphocytic infiltrates
  • Chronic atypical hepatitis
  • Her
  • Immunodeficiency
  • Virus-associated lymphoproliferatiue disease


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