Immunodeficiency-disease-associated atypical chronic hepatitis: A clinicopathologic study

Dale C. Snover, A. H. Filipovich, Louis P. Dehner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chronic hepatitis occurring in patients with primary immunodeficiency disease is an uncommonly reported phenomenon. This study describes our experience with 3 patients with various immunologic abnormalities who developed chronic atypical lymphocytic infiltrates in the liver. There was a temporal relationship to Epstein-Barr Virus infection in 2 cases and hepatitis A in 1. In view of the increased incidence of malignant lymphoma in several of the primary immunodeficiency states, these cases present a difficult diagnostic challenge. The recognition of the association of infiltration of the liver with small cleaved lymphocytes and a viral infection in an immunodeficient patient should alert the pathologist to the possibility that the infiltrate does not represent malignant lymphoma. These cases may be analogous to similar virus-associated lymphoproliferative disorders described in the acquired immunodeficiency of renal transplantation..

Original languageEnglish
Pages (from-to)229-241
Number of pages13
JournalFetal and Pediatric Pathology
Volume1
Issue number2
DOIs
StatePublished - 1983

Keywords

  • Atypical lymphocytic infiltrates
  • Chronic atypical hepatitis
  • Her
  • Immunodeficiency
  • Virus-associated lymphoproliferatiue disease

Fingerprint

Dive into the research topics of 'Immunodeficiency-disease-associated atypical chronic hepatitis: A clinicopathologic study'. Together they form a unique fingerprint.

Cite this