Immunocytochemical Studies on B Lymphocytes from the Biozzi High and Low Lines of Mice Selected for Their Responses to Heterologous Erythrocytes

Emil R. Unanue, Guido Biozzi, Baruj Benacerraf

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Abstract

The high and low antibody producing lines of mice developed by Biozzi were studied immunocytochemically in an attempt to determine several parameters of B lymphocyte function. At 8–9 weeks of age, both lines contain the same number of B cells in spleen, lymph node and thymus. The B cells of the high line contain about one-third more surface Ig; the distribution of surface Ig in cells of both lines as well as the redistribution of the surface Ig-anti Ig complexes were identical. At 13–14 weeks of age, the number of B cells was higher in the high antibody producing mice; at this age, however, the mean content of Ig per B lymphocyte was identical.

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume145
Issue number4
DOIs
StatePublished - Apr 1974

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