Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient

R. C. Griffith, B. K. Saha, C. M. Janney, L. Ratner, E. M. Brunt, K. J. Gajl-Peczalska, D. W. Hanto

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30 Scopus citations

Abstract

A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalAmerican journal of clinical pathology
Volume93
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Keywords

  • T-cell lymphoma
  • immunoblastic lymphoma
  • renal transplant

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