TY - JOUR
T1 - Immunization with persistent attenuated Δlpg2 Leishmania major parasites requires adjuvant to provide protective immunity in C57BL/6 mice
AU - Kébaïer, Chahnaz
AU - Uzonna, Jude E.
AU - Beverley, Stephen M.
AU - Scott, Phillip
PY - 2006/1
Y1 - 2006/1
N2 - Leishmania major parasites lacking the GDP-mannose transporter, termed Δlpg2 parasites, fail to induce disease in mice but persist long-term. We previously found that Δlpg2 organisms protect BALB/c mice from virulent L. major challenge. In contrast, we report here that Δlpg2 parasites induce protective immunity in C57BL/6 mice only when administered with CpG-containing oligodeoxynucleotides, indicating that parasite persistence alone is not sufficient to maintain protective immunity to L. major.
AB - Leishmania major parasites lacking the GDP-mannose transporter, termed Δlpg2 parasites, fail to induce disease in mice but persist long-term. We previously found that Δlpg2 organisms protect BALB/c mice from virulent L. major challenge. In contrast, we report here that Δlpg2 parasites induce protective immunity in C57BL/6 mice only when administered with CpG-containing oligodeoxynucleotides, indicating that parasite persistence alone is not sufficient to maintain protective immunity to L. major.
UR - http://www.scopus.com/inward/record.url?scp=29644439033&partnerID=8YFLogxK
U2 - 10.1128/IAI.74.1.777-780.2006
DO - 10.1128/IAI.74.1.777-780.2006
M3 - Article
C2 - 16369039
AN - SCOPUS:29644439033
SN - 0019-9567
VL - 74
SP - 777
EP - 780
JO - Infection and Immunity
JF - Infection and Immunity
IS - 1
ER -