Immunity to seasonal and pandemic influenza A viruses

Sophie A. Valkenburg, John A. Rutigliano, Ali H. Ellebedy, Peter C. Doherty, Paul G. Thomas, Katherine Kedzierska

Research output: Contribution to journalShort surveypeer-review

48 Scopus citations

Abstract

The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain.

Original languageEnglish
Pages (from-to)489-501
Number of pages13
JournalMicrobes and Infection
Volume13
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • Adaptive immunity
  • Antigenic variation
  • H1N1 2009
  • Influenza virus
  • Innate immunity

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