TY - JOUR
T1 - Immunity and cognition
T2 - what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
AU - Kipnis, Jonathan
AU - Derecki, Noel Christopher
AU - Yang, Chunhui
AU - Scrable, Heidi
PY - 2008/10
Y1 - 2008/10
N2 - Until recently, dogma dictated that the immune system and the central nervous system (CNS) live mostly separate, parallel lives, and any interactions between the two were assumed to be limited to extreme cases of pathological insult. It was only a decade ago that T cells in the injured brain were shown to play a protective rather than a destructive role. In this article, we explore the role of the immune system in the healthy brain, focusing on the key function that T lymphocytes have in the regulation of cognition. We discuss candidate mechanisms underlying T cell-mediated control of cognitive function in human cognitive diseases associated with immune decline, such as age- and HIV-related dementias, 'chemo-brain' and others.
AB - Until recently, dogma dictated that the immune system and the central nervous system (CNS) live mostly separate, parallel lives, and any interactions between the two were assumed to be limited to extreme cases of pathological insult. It was only a decade ago that T cells in the injured brain were shown to play a protective rather than a destructive role. In this article, we explore the role of the immune system in the healthy brain, focusing on the key function that T lymphocytes have in the regulation of cognition. We discuss candidate mechanisms underlying T cell-mediated control of cognitive function in human cognitive diseases associated with immune decline, such as age- and HIV-related dementias, 'chemo-brain' and others.
UR - http://www.scopus.com/inward/record.url?scp=52049111222&partnerID=8YFLogxK
U2 - 10.1016/j.it.2008.07.007
DO - 10.1016/j.it.2008.07.007
M3 - Article
C2 - 18789764
AN - SCOPUS:52049111222
SN - 1471-4906
VL - 29
SP - 455
EP - 463
JO - Trends in Immunology
JF - Trends in Immunology
IS - 10
ER -