Immune responses to self-antigens in asthma patients: Clinical and immunopathological implications

Michael Liu, Vijay Subramanian, Chandrika Christie, Mario Castro, Thallachallour Mohanakumar

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Asthma leads to chronic airway inflammation that shares pathological features of chronic rejection after lung transplantation. Due to the significant role of autoimmunity in chronic rejection, we hypothesized that immunity to self-antigens may also be present in asthma. The goal was to define immune responses to self-antigens in patients with asthma. Blood and clinical data were collected from 99 asthmatics and 60 controls. Serum was analyzed for antibodies (Abs) to collagen V (ColV) by enzyme-linked immunosorbent assay and correlated with disease severity. Asthmatics' sera were tested in a human protein array to determine immune responses to other self-antigens. Asthmatics had higher concentrations of Abs to ColV (predominantly immunoglobulin G isotype) compared with controls (p < 0.01). These Abs correlated with severe asthma (p < 0.01) and corticosteroid use (p = 0.032). Additionally, Abs to novel self-antigens epidermal group factor receptor (EGFr), activin A type 1 receptor, and α-catenin were detected in asthmatics. We conclude that Abs to self-antigens (ColV, EGFr, activin A type 1 receptor, and α-catenin) are present in the sera of asthmatics, correlating with clinical disease. Epithelial damage from airway inflammation during asthma may result in the exposure of cryptic self-antigens or their determinants, resulting in immune response to self-antigens, which may contribute to the pathogenesis of asthma.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalHuman Immunology
Volume73
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • Activin A type 1 receptor
  • Asthma
  • Autoimmunity
  • Collagen V
  • Epidermal growth factor receptor
  • α-Catenin

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