Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination

Ben Wen Li; Shaorong Zhang; Kurt C. Curtis; Gary J. Weil

doi:10.1016/S0264-410X(99)00182-6

Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination

Ben Wen Li, Shaorong Zhang, Kurt C. Curtis, Gary J. Weil

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Immunization with recombinant Brugia malayi paramyosin protein (BM5) induces partial immunity to this filarial nematode in jirds. The present study examined the effects of intramuscular immunization with plasmid DNA that encodes BM5. DNA-immunized mice produced strong antibody and cell- mediated responses to paramyosin. The protective activity of DNA vaccination with BM5 was tested in jirds. Vaccinated jirds produced strong antibody responses to paramyosin, but adult worm recoveries after challenge were not decreased in vaccinated animals relative to controls. These studies show that DNA vaccination can induce immune responses to filarial antigens in rodents. Further efforts will be needed to achieve the goal of inducing protective immunity to filariasis with this promising new technology.

Original language	English
Pages (from-to)	76-81
Number of pages	6
Journal	Vaccine
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1016/S0264-410X(99)00182-6
State	Published - Aug 20 1999

Keywords

Brugia malayi
DNA vaccine
Paramyosin

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10.1016/S0264-410X(99)00182-6

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title = "Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination",

abstract = "Immunization with recombinant Brugia malayi paramyosin protein (BM5) induces partial immunity to this filarial nematode in jirds. The present study examined the effects of intramuscular immunization with plasmid DNA that encodes BM5. DNA-immunized mice produced strong antibody and cell- mediated responses to paramyosin. The protective activity of DNA vaccination with BM5 was tested in jirds. Vaccinated jirds produced strong antibody responses to paramyosin, but adult worm recoveries after challenge were not decreased in vaccinated animals relative to controls. These studies show that DNA vaccination can induce immune responses to filarial antigens in rodents. Further efforts will be needed to achieve the goal of inducing protective immunity to filariasis with this promising new technology.",

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T1 - Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination

AU - Li, Ben Wen

AU - Zhang, Shaorong

AU - Curtis, Kurt C.

AU - Weil, Gary J.

PY - 1999/8/20

Y1 - 1999/8/20

N2 - Immunization with recombinant Brugia malayi paramyosin protein (BM5) induces partial immunity to this filarial nematode in jirds. The present study examined the effects of intramuscular immunization with plasmid DNA that encodes BM5. DNA-immunized mice produced strong antibody and cell- mediated responses to paramyosin. The protective activity of DNA vaccination with BM5 was tested in jirds. Vaccinated jirds produced strong antibody responses to paramyosin, but adult worm recoveries after challenge were not decreased in vaccinated animals relative to controls. These studies show that DNA vaccination can induce immune responses to filarial antigens in rodents. Further efforts will be needed to achieve the goal of inducing protective immunity to filariasis with this promising new technology.

AB - Immunization with recombinant Brugia malayi paramyosin protein (BM5) induces partial immunity to this filarial nematode in jirds. The present study examined the effects of intramuscular immunization with plasmid DNA that encodes BM5. DNA-immunized mice produced strong antibody and cell- mediated responses to paramyosin. The protective activity of DNA vaccination with BM5 was tested in jirds. Vaccinated jirds produced strong antibody responses to paramyosin, but adult worm recoveries after challenge were not decreased in vaccinated animals relative to controls. These studies show that DNA vaccination can induce immune responses to filarial antigens in rodents. Further efforts will be needed to achieve the goal of inducing protective immunity to filariasis with this promising new technology.

KW - Brugia malayi

KW - DNA vaccine

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Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination

Abstract

Keywords

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