Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination

Ben Wen Li, Shaorong Zhang, Kurt C. Curtis, Gary J. Weil

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Immunization with recombinant Brugia malayi paramyosin protein (BM5) induces partial immunity to this filarial nematode in jirds. The present study examined the effects of intramuscular immunization with plasmid DNA that encodes BM5. DNA-immunized mice produced strong antibody and cell- mediated responses to paramyosin. The protective activity of DNA vaccination with BM5 was tested in jirds. Vaccinated jirds produced strong antibody responses to paramyosin, but adult worm recoveries after challenge were not decreased in vaccinated animals relative to controls. These studies show that DNA vaccination can induce immune responses to filarial antigens in rodents. Further efforts will be needed to achieve the goal of inducing protective immunity to filariasis with this promising new technology.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalVaccine
Volume18
Issue number1-2
DOIs
StatePublished - Aug 20 1999

Keywords

  • Brugia malayi
  • DNA vaccine
  • Paramyosin

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