Immune regulation of viral infection and vice versa

Herbert W. Virgin

doi:10.1385/IR:32:1-3:293

Immune regulation of viral infection and vice versa

Herbert W. Virgin

Division of Immunobiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding acute and chronic diseases caused by viruses. Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms.

Original language	English
Pages (from-to)	293-315
Number of pages	23
Journal	Immunologic Research
Volume	32
Issue number	1-3
DOIs	https://doi.org/10.1385/IR:32:1-3:293
State	Published - 2005

Keywords

Herpesvirus
Latency
Norovirus
Pathogenesis
Vaccination

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10.1385/IR:32:1-3:293

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title = "Immune regulation of viral infection and vice versa",

abstract = "In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding acute and chronic diseases caused by viruses. Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms.",

keywords = "Herpesvirus, Latency, Norovirus, Pathogenesis, Vaccination",

author = "Virgin, {Herbert W.}",

note = "Funding Information: This work was supported by grants R01 CA74730, R01 HL60090, R01 CA96511, R01 AI45019, and R01 AI54483 from the National Institutes of Health.",

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AU - Virgin, Herbert W.

N1 - Funding Information: This work was supported by grants R01 CA74730, R01 HL60090, R01 CA96511, R01 AI45019, and R01 AI54483 from the National Institutes of Health.

PY - 2005

Y1 - 2005

N2 - In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding acute and chronic diseases caused by viruses. Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms.

AB - In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding acute and chronic diseases caused by viruses. Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms.

KW - Herpesvirus

KW - Latency

KW - Norovirus

KW - Pathogenesis

KW - Vaccination

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SN - 0257-277X

VL - 32

SP - 293

EP - 315

JO - Immunologic Research

JF - Immunologic Research

IS - 1-3

ER -

Immune regulation of viral infection and vice versa

Abstract

Keywords

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