TY - JOUR
T1 - Immune regulation of metabolic homeostasis in health and disease
AU - Brestoff, Jonathan R.
AU - Artis, David
N1 - Funding Information:
The authors wish to thank members of the Artis laboratory for the critical reading of this manuscript. Research in the Artis lab is supported by the NIH (AI061570, AI074878, AI095466, AI095608, AI102942, AI106697, and AI097333 to D.A.), the Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Disease Award (D.A.) and Crohn’s and Colitis Foundation of America (D.A.). Additional funding was provided by NIH F30-AI112023 and T32-AI060516 to J.R.B.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/3/26
Y1 - 2015/3/26
N2 - Obesity is an increasingly prevalent disease worldwide. While genetic and environmental factors are known to regulate the development of obesity and associated metabolic diseases, emerging studies indicate that innate and adaptive immune cell responses in adipose tissue have critical roles in the regulation of metabolic homeostasis. In the lean state, type 2 cytokine-associated immune cell responses predominate in white adipose tissue and protect against weight gain and insulin resistance through direct effects on adipocytes and elicitation of beige adipose. In obesity, these metabolically beneficial immune pathways become dysregulated, and adipocytes and other factors initiate metabolically deleterious type 1 inflammation that impairs glucose metabolism. This review discusses our current understanding of the functions of different types of adipose tissue and how immune cells regulate adipocyte function and metabolic homeostasis in the context of health and disease and highlights. We also highlight the potential of targeting immuno-metabolic pathways as a therapeutic strategy to treat obesity and associated diseases.
AB - Obesity is an increasingly prevalent disease worldwide. While genetic and environmental factors are known to regulate the development of obesity and associated metabolic diseases, emerging studies indicate that innate and adaptive immune cell responses in adipose tissue have critical roles in the regulation of metabolic homeostasis. In the lean state, type 2 cytokine-associated immune cell responses predominate in white adipose tissue and protect against weight gain and insulin resistance through direct effects on adipocytes and elicitation of beige adipose. In obesity, these metabolically beneficial immune pathways become dysregulated, and adipocytes and other factors initiate metabolically deleterious type 1 inflammation that impairs glucose metabolism. This review discusses our current understanding of the functions of different types of adipose tissue and how immune cells regulate adipocyte function and metabolic homeostasis in the context of health and disease and highlights. We also highlight the potential of targeting immuno-metabolic pathways as a therapeutic strategy to treat obesity and associated diseases.
UR - http://www.scopus.com/inward/record.url?scp=84925873107&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2015.02.022
DO - 10.1016/j.cell.2015.02.022
M3 - Review article
C2 - 25815992
AN - SCOPUS:84925873107
SN - 0092-8674
VL - 161
SP - 146
EP - 160
JO - Cell
JF - Cell
IS - 1
M1 - 8053
ER -