TY - JOUR
T1 - Immune-mediated protection and pathogenesis of chikungunya virus
AU - Fox, Julie M.
AU - Diamond, Michael S.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants R01 AI073755, R01 AI104972, and R01 AI114816. J.M.F. was supported by National Institutes of Health Grant T32 AI007172.
Publisher Copyright:
© 2016 by The American Association of Immunologists, Inc. All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis.
AB - Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84996553936&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1601426
DO - 10.4049/jimmunol.1601426
M3 - Review article
C2 - 27864552
AN - SCOPUS:84996553936
SN - 0022-1767
VL - 197
SP - 4210
EP - 4218
JO - Journal of Immunology
JF - Journal of Immunology
IS - 11
ER -