Immune-mediated protection and pathogenesis of chikungunya virus

Julie M. Fox, Michael S. Diamond

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis.

Original languageEnglish
Pages (from-to)4210-4218
Number of pages9
JournalJournal of Immunology
Volume197
Issue number11
DOIs
StatePublished - Dec 1 2016

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