Immune-Mediated Glomerular Injury

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Immune-mediated glomerular disease is typified by membranous glomerulonephritis (MGN), lupus nephritis, and postinfectious glomerulonephritis (PIGN). Immune-mediated refers to the presence of immune complexes on a renal biopsy. The mechanisms responsible for formation and deposition of these complexes depend on the specific disease entity. However, once deposited, glomerular injury is mediated by both classical and alternative complement system activation and inflammatory cell recruitment. Animal models and large-scale genetic studies have significantly enhanced our understanding of the pathophysiological mechanisms underlying immune complex disease susceptibiLity and disease progression. However, it should be emphasized that animal models of MGN, lupus nephritis, and PIGN have significant flaws. A thorough understanding of the inflammatory mediators and genetic underpinnings of these diseases is critical to development of effective therapeutics and prevention strategies.

Original languageEnglish
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages2788-2801
Number of pages14
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - Jan 1 2014

Keywords

  • Antinuclear antibodies
  • Complement
  • Hematuria
  • Heymann nephritis
  • Immune complex glomerulonephritis
  • Lupus nephritis
  • Membranous glomerulonephritis
  • Postinfectious glomerulonephritis
  • Proteinuria

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