Immune hemolysis involving non-ABO/RhD alloantibodies following hematopoietic stem cell transplantation

P. P. Young, L. T. Goodnough, P. Westervelt, J. F. Dipersio

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We report two cases of severe alloimmune hemolysis after hematopoietic stem cell (HSC) transplant resulting from an anti-Jka. The time course of hemolysis and Jk phenotypes of the donor and recipient in the cases reported suggest that the antibody was produced by donor-derived passenger lymphocytes. Retrospective analysis of the blood bank records of all allogeneic HSC transplant patients at Barnes-Jewish Hospital from 1994 to 1999 suggests that the incidence of alloimmune hemolysis due to incompatibilities involving non-ABO or RhD red cell antigens is very low, approximately 1%. In one patient, the duration of hemolysis was shortened significantly by performing red cell exchange at the first sign of intravascular hemolysis.

Original languageEnglish
Pages (from-to)1305-1310
Number of pages6
JournalBone Marrow Transplantation
Volume27
Issue number12
DOIs
StatePublished - 2001

Keywords

  • Alloantibodies
  • Allotransplantation
  • Hemolysis
  • Stem cells

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