There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

Original languageEnglish
Pages (from-to)304-316
Number of pages13
JournalNature Reviews Immunology
Issue number4
StatePublished - Apr 2003


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