TY - JOUR
T1 - Immune functions encoded by the natural killer gene complex
AU - Yokoyama, Wayne M.
AU - Plougastel, Beatrice F.M.
N1 - Funding Information:
We gratefully acknowledge M. Colonna for discussion of unpublished work, A. Diefenbach and D. Raulet for sharing an unpublished manuscript, and L. Carayannopoulos, T. French and H. Smith for critical evaluation of this manuscript. Work in the Yokoyama laboratory is supported by the Barnes-Jewish Hospital Research Foundation, National Institutes of Health and Howard Hughes Medical Institute. We apologize to our colleagues for not being able to cite additional studies due to space constraints.
PY - 2003/4
Y1 - 2003/4
N2 - There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.
AB - There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.
UR - http://www.scopus.com/inward/record.url?scp=0038316337&partnerID=8YFLogxK
U2 - 10.1038/nri1055
DO - 10.1038/nri1055
M3 - Review article
C2 - 12669021
AN - SCOPUS:0038316337
SN - 1474-1733
VL - 3
SP - 304
EP - 316
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 4
ER -