Immune functions encoded by the natural killer gene complex

Research output: Contribution to journalReview article

445 Scopus citations


There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

Original languageEnglish
Pages (from-to)304-316
Number of pages13
JournalNature Reviews Immunology
Issue number4
StatePublished - Apr 2003

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