Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFNg priming

Keyphrases

• Mesenchymal Stromal Cells 100%
• Interferon-γ 100%
• Dysfunctionality 100%
• T Cell Proliferation 17%
• CXCL10 11%
• Granulocyte Colony-stimulating Factor (G-CSF) 11%
• Vascular Endothelial Growth Factor 11%
• Indoleamine 2,3-dioxygenase 1 (IDO1) 11%
• Kynurenine 11%
• Cell Co-culture 11%
• Immunomodulatory Properties 11%
• Chemokine Ligand 2 (CCL2) 11%
• Exogenous Addition 11%
• Interleukin-1 Receptor Antagonist (IL-1Ra) 5%
• Tumor Necrosis Factor-α 5%
• Clinical Trials 5%
• Cell Cycle Arrest 5%
• Peripheral Blood Mononuclear Cells 5%
• β-Galactosidase (β-Gal) 5%
• Fibroblast Growth Factor 1 (FGF1) 5%
• Carbon Tetrachloride 5%
• Immunomodulatory Effect 5%
• Interleukin-5 (IL-5) 5%
• T-cell Cytokines 5%
• CXCL9 5%
• CXCL11 5%
• Functional Defects 5%
• Cytokine Secretion 5%
• HLA-DR 5%
• Secretome Analysis 5%
• Soluble interleukin-2 Receptor (sIL-2R) 5%
• Cell Surface Display 5%
• Cellular Hypertrophy 5%
• Replicative Senescence 5%
• Cell Functionality 5%
• Immunomodulatory Genes 5%
• Scale Expansion 5%
• Lung Homing 5%
• Cytokines/chemokines 5%

Biochemistry, Genetics and Molecular Biology

• Stromal Cell 100%
• T Cell 17%
• Cell Proliferation 17%
• Vascular Endothelial Growth Factor 11%
• Coculture 11%
• Granulocyte Colony-Stimulating Factor 11%
• Indoleamine 2,3-dioxygenase 11%
• CCL2 11%
• CXCL10 11%
• Kynurenine 11%
• Cytokine 5%
• Cell Cycle Arrest 5%
• Clinical Trial 5%
• Peripheral Blood Mononuclear Cell 5%
• Basic Fibroblast Growth Factor 5%
• Interleukin 5 5%
• Chemokine 5%
• Tumor Necrosis Factor Alpha 5%
• Secretome 5%
• Cytokine Release 5%
• Cell Cycle Checkpoint 5%
• CXCL9 5%
• CXCL11 5%
• HLA-DR 5%
• CCL4 5%
• Galactosidase 5%

Immunology and Microbiology

• Mesenchymal Stem Cell 100%
• Immunosuppressive Drug 17%
• T Cell Proliferation 17%
• CXCL10 11%
• Granulocyte Colony-Stimulating Factor 11%
• Coculture 11%
• Vasculotropin 11%
• CCL2 11%
• Indoleamine 2,3-dioxygenase 11%
• Cytokine 5%
• Chemokine 5%
• Interleukin 5 5%
• CXCL9 5%
• CXCL11 5%
• Fibroblast Growth Factor 2 5%
• Tumor Necrosis Factor Alpha 5%
• Cell Cycle Arrest 5%
• Cytokine Release 5%
• Secretome 5%
• HLA-DR 5%
• Cell Cycle Checkpoint 5%
• Peripheral Blood Mononuclear Cell 5%
• Galactosidase 5%
• In Vitro 5%
• Lung 5%