TY - JOUR
T1 - Immune and nervous system CXCL12 and CXCR4
T2 - Parallel roles in patterning and plasticity
AU - Klein, Robyn S.
AU - Rubin, Joshua B.
N1 - Funding Information:
We wish to thank Jonathon Gitlin, Louis Muglia and Mark Poznansky for their critical reading of the manuscript and helpful comments. R.S.K is supported by NIH/NINDS K02NS045607, National Multiple Sclerosis grant RG3450A1/2 and a grant from the Washington University/Pfizer Biomedical Program. J.B.R. is supported by NIH/NICHHD KO8HD01393, the American Cancer Society IRG-58-010-47 and is a Scholar of the Child Health Research Center of Excellence in Developmental Biology at Washington University School of Medicine (K12-HD01487). We extend our apologies to those whose work could not be cited due to space limitation.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - Recent data suggest that CXCL12 and CXCR4 have parallel effects in the immune and nervous systems; they regulate cellular movement, proliferation, plasticity and survival of neurons and lymphocytes. Parallel reliance on CXCL12 might support coordinated homeostatic interactions between the nervous and immune systems but might also constitute a unique vulnerability to inflammatory processes, such as HIV-1 infection, that target CXCR4.
AB - Recent data suggest that CXCL12 and CXCR4 have parallel effects in the immune and nervous systems; they regulate cellular movement, proliferation, plasticity and survival of neurons and lymphocytes. Parallel reliance on CXCL12 might support coordinated homeostatic interactions between the nervous and immune systems but might also constitute a unique vulnerability to inflammatory processes, such as HIV-1 infection, that target CXCR4.
UR - http://www.scopus.com/inward/record.url?scp=2342545918&partnerID=8YFLogxK
U2 - 10.1016/j.it.2004.04.002
DO - 10.1016/j.it.2004.04.002
M3 - Review article
C2 - 15145320
AN - SCOPUS:2342545918
SN - 1471-4906
VL - 25
SP - 306
EP - 314
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -