Imaging systemic inflammatory networks in ischemic heart disease

Matthias Nahrendorf, Stefan Frantz, Filip K. Swirski, Willem J.M. Mulder, Gwendalyn Randolph, Georg Ertl, Vasilis Ntziachristos, Jan J. Piek, Erik S. Stroes, Markus Schwaiger, Douglas L. Mann, Zahi A. Fayad

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

While acute myocardial infarction mortality declines, patients continue to face reinfarction and/or heart failure. The immune system, which intimately interacts with healthy and diseased tissues through resident and recruited leukocytes, is a central interface for a global host response to ischemia. Pathways that enhance the systemic leukocyte supply may be potential therapeutic targets. Pre-clinically, imaging helps to identify immunity's decision nodes, which may serve as such targets. In translating the rapidly-expanding pre-clinical data on immune activity, the difficulty of obtaining multiple clinical tissue samples from involved organs is an obstacle that whole-body imaging can help overcome. In patients, molecular and cellular imaging can be integrated with blood-based diagnostics to assess the translatability of discoveries, including the activation of hematopoietic tissues after myocardial infarction, and serve as an endpoint in clinical trials. In this review, we discuss these concepts while focusing on imaging immune activity in organs involved in ischemic heart disease.

Original languageEnglish
Pages (from-to)1583-1591
Number of pages9
JournalJournal of the American College of Cardiology
Volume65
Issue number15
DOIs
StatePublished - Apr 21 2015

Keywords

  • atherosclerosis
  • heart failure
  • hematopoiesis
  • leukocytes
  • myocardial infarction
  • spleen

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