Imaging spectrum of granulomatous diseases of the Abdomen and Pelvis

Muhammad Naeem, Christine O. Menias, Austin J. Cail, Maria Zulfiqar, David H. Ballard, Perry J. Pickhardt, David H. Kim, Meghan G. Lubner, Vincent Mellnick

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A granuloma is a compact organization of mature macrophages that forms because of persistent antigenic stimulation. At the microscopic level, granulomas can undergo various morphologic changes, ranging from necrosis to fibrosis, which along with other specialized immune cells define the appearance of the granulomatous process. Accordingly, the imaging features of granulomatous diseases vary and can overlap with those of other diseases, such as malignancy, and lead to surgical excisions and biopsy. However, given the het-erogeneity of granulomas as a disease group, it is often hard to make a diagnosis on the basis of the histopathologic features of granulomatous diseases alone owing to overlapping microscopic features. Instead, a multidisciplinary approach is often helpful. Radiologists need to be familiar with the salient clinical manifestations and imaging findings of granulomatous diseases to generate an appropriate differential diagnosis.

Original languageEnglish
Pages (from-to)783-801
Number of pages19
Issue number3
StatePublished - May 1 2021


Dive into the research topics of 'Imaging spectrum of granulomatous diseases of the Abdomen and Pelvis'. Together they form a unique fingerprint.

Cite this