TY - GEN
T1 - Imaging of focused ultrasound-induced shear waves to probe mechanical anisotropy of tissue
AU - Guertler, Charlotte A.
AU - Okamoto, Ruth J.
AU - Garbow, Joel R.
AU - Chen, Hong
AU - Bayly, Philip V.
N1 - Publisher Copyright:
© 2021 by ASME.
PY - 2021
Y1 - 2021
N2 - It is important to understand mechanical anisotropy in fibrous soft tissues because of the relationship of anisotropy to tissue function, and because anisotropy may change due to injury and disease. We have developed a method to noninvasively investigate anisotropy, based on MR imaging of harmonic ultrasound-induced motion (MR-HUM), using focused ultrasound (FUS) and magnetic resonance elastography (MRE). MR-HUM produces symmetric, radial waves inside a tissue, which enables a simple assessment of anisotropy using features of the resulting shear wave fields. This method was applied to characterize ex vivo muscle tissue, which is known to exhibit mechanical anisotropy. Finite element (FE) simulations of the experiment were performed to illustrate and validate the approach. Anisotropy was characterized by ratios of apparent shear moduli and strain components in different directions.
AB - It is important to understand mechanical anisotropy in fibrous soft tissues because of the relationship of anisotropy to tissue function, and because anisotropy may change due to injury and disease. We have developed a method to noninvasively investigate anisotropy, based on MR imaging of harmonic ultrasound-induced motion (MR-HUM), using focused ultrasound (FUS) and magnetic resonance elastography (MRE). MR-HUM produces symmetric, radial waves inside a tissue, which enables a simple assessment of anisotropy using features of the resulting shear wave fields. This method was applied to characterize ex vivo muscle tissue, which is known to exhibit mechanical anisotropy. Finite element (FE) simulations of the experiment were performed to illustrate and validate the approach. Anisotropy was characterized by ratios of apparent shear moduli and strain components in different directions.
KW - Anisotropy
KW - Experiment
KW - FE simulation
KW - Focused ultrasound
KW - Magnetic resonance elastography
UR - http://www.scopus.com/inward/record.url?scp=85107237751&partnerID=8YFLogxK
U2 - 10.1115/DMD2021-1030
DO - 10.1115/DMD2021-1030
M3 - Conference contribution
AN - SCOPUS:85107237751
T3 - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
BT - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PB - American Society of Mechanical Engineers
T2 - 2021 Design of Medical Devices Conference, DMD 2021
Y2 - 12 April 2021 through 15 April 2021
ER -