It is important to understand mechanical anisotropy in fibrous soft tissues because of the relationship of anisotropy to tissue function, and because anisotropy may change due to injury and disease. We have developed a method to noninvasively investigate anisotropy, based on MR imaging of harmonic ultrasound-induced motion (MR-HUM), using focused ultrasound (FUS) and magnetic resonance elastography (MRE). MR-HUM produces symmetric, radial waves inside a tissue, which enables a simple assessment of anisotropy using features of the resulting shear wave fields. This method was applied to characterize ex vivo muscle tissue, which is known to exhibit mechanical anisotropy. Finite element (FE) simulations of the experiment were performed to illustrate and validate the approach. Anisotropy was characterized by ratios of apparent shear moduli and strain components in different directions.

Original languageEnglish
Title of host publicationProceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791884812
StatePublished - 2021
Event2021 Design of Medical Devices Conference, DMD 2021 - Virtual, Online
Duration: Apr 12 2021Apr 15 2021

Publication series

NameProceedings of the 2021 Design of Medical Devices Conference, DMD 2021


Conference2021 Design of Medical Devices Conference, DMD 2021
CityVirtual, Online


  • Anisotropy
  • Experiment
  • FE simulation
  • Focused ultrasound
  • Magnetic resonance elastography


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