Imaging Myocardial Metabolism

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

It has long been recognized that abnormalities in myocardial substrate metabolism play a central role in the manifestations of most forms of cardiovascular disease such as ischemic heart disease, heart failure, hypertensive heart disease, and the cardiomyopathy due to either obesity or diabetes mellitus. Prolonged changes in metabolism lead to chronic adaptations, so-called metabolic remodeling, that initiates a host of pleiotropic actions detrimental to cellular health such as impaired energetics and increases in inflammation, oxidative stress, and apoptosis. In parallel with the growth in understanding of these metabolic underpinnings has been the explosive development of imaging tools such as positron emission tomography, single-photon emission computed tomography, and magnetic resonance imaging, spectroscopy, particularly carbon-13 hyperpolarized magnetic resonance spectroscopy that can measure metabolic processes. This chapter will summarize the fundamentals of myocardial metabolic remodeling, where the various imaging modalities can assess key metabolic pathways and clinical and research applications for metabolic imaging.

Original languageEnglish
Title of host publicationMolecular Imaging
Subtitle of host publicationPrinciples and Practice
PublisherElsevier
Pages1149-1165
Number of pages17
ISBN (Electronic)9780128163863
ISBN (Print)9780128163870
DOIs
StatePublished - Jan 1 2021

Keywords

  • Cardiovascular disease
  • Diabetes mellitus
  • Heart failure
  • Hyperpolarized magnetic spectroscopy
  • Imaging
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Myocardial metabolism
  • Obesity
  • Positron emission tomography
  • Single-photon emission computed tomography

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