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The disease-causing genetic information might reside in the genomic DNA or RNA, or in a virus, bacterium, or other pathogen, or from alterations in the methylation pattern of DNA, which in turn alters RNA expression levels. A much more attractive and universal intracellular target from a design point of view would be to directly target genetic information associated with a disease state because information in the form of DNA or RNA can in principle be easily recognized by Watson-Crick base pairing with an antisense oligonucleotide. There are two general classes of reporter systems that can be used such as always ON and turn-on reporter systems. Most of the literature concerning genetically targeted nanoparticle (NP), deals with siRNA and gene therapy, and very little deals with antisense imaging.

Original languageEnglish
Title of host publicationNanotechnology for Biomedical Imaging and Diagnostics
Subtitle of host publicationFrom Nanoparticle Design to Clinical Applications
Number of pages28
ISBN (Electronic)9781118873151
ISBN (Print)9781118121184
StatePublished - Jan 30 2015


  • Antisense imaging
  • Nanoparticle
  • Nucleic acids
  • Reporter systems


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