The disease-causing genetic information might reside in the genomic DNA or RNA, or in a virus, bacterium, or other pathogen, or from alterations in the methylation pattern of DNA, which in turn alters RNA expression levels. A much more attractive and universal intracellular target from a design point of view would be to directly target genetic information associated with a disease state because information in the form of DNA or RNA can in principle be easily recognized by Watson-Crick base pairing with an antisense oligonucleotide. There are two general classes of reporter systems that can be used such as always ON and turn-on reporter systems. Most of the literature concerning genetically targeted nanoparticle (NP), deals with siRNA and gene therapy, and very little deals with antisense imaging.
|Title of host publication||Nanotechnology for Biomedical Imaging and Diagnostics|
|Subtitle of host publication||From Nanoparticle Design to Clinical Applications|
|Number of pages||28|
|State||Published - Jan 30 2015|
- Antisense imaging
- Nucleic acids
- Reporter systems