Imaging features of neurofibromatosis type 1 in the abdomen and pelvis

Maria Zulfiqar, Michael Lin, Kristy Ratkowski, Marie Helene Gagnon, Christine Menias, Cary Lynn Siegel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


OBJECTIVE. Loss of the neurofibromatosis type 1 (NF1) tumor suppressor protein causes uninhibited activation of the RAS oncogene, which leads to tumorigenesis in patients with NF1. This case-based review discusses imaging manifestations of NF1 in the abdomen and pelvis, highlighting key genetic associations and management to elucidate features different from the general population. CONCLUSION. The spectrum of pathologic findings includes gastrointestinal tumors such as gastrointestinal stromal tumors, genitourinary lesions including urogenital neurofibromas, vascular entities such as renal artery stenosis, and less common associations like lymphoma.

Original languageEnglish
Pages (from-to)241-251
Number of pages11
JournalAmerican Journal of Roentgenology
Issue number1
StatePublished - Jan 2021


  • Lymphoma
  • Malignant peripheral nerve sheath tumor
  • Neurofibroma
  • Neurofibromatosis type 1
  • Paraganglioma
  • Pheochromocytoma
  • Renal artery stenosis


Dive into the research topics of 'Imaging features of neurofibromatosis type 1 in the abdomen and pelvis'. Together they form a unique fingerprint.

Cite this