Imaging dopamine receptors in the human brain by positron tomography

Henry N. Wagner; H. Donald Burns; Robert E. Dannals; Dean F. Wong; Bengt Langstrom; Timothy Duelfer; J. James Frost; Hayden T. Ravert; Jonathan M. Links; Shelley B. Rosenbloom; Scott E. Lukas; Alfred V. Kramer; Michael J. Kuhar

doi:10.1126/science.6604315

Imaging dopamine receptors in the human brain by positron tomography

Henry N. Wagner, H. Donald Burns, Robert E. Dannals, Dean F. Wong, Bengt Langstrom, Timothy Duelfer, J. James Frost, Hayden T. Ravert, Jonathan M. Links, Shelley B. Rosenbloom, Scott E. Lukas, Alfred V. Kramer, Michael J. Kuhar

Precision Radio-Theranostics Translational Laboratories (PRT2L)

Research output: Contribution to journal › Article › peer-review

547 Scopus citations

Abstract

Neurotransmitter receptors may be involved in a number of neuropsy chiatric disease states. The ligand 3-N-[¹¹C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.

Original language	English
Pages (from-to)	1264-1266
Number of pages	3
Journal	Science
Volume	221
Issue number	4617
DOIs	https://doi.org/10.1126/science.6604315
State	Published - 1983

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title = "Imaging dopamine receptors in the human brain by positron tomography",

abstract = "Neurotransmitter receptors may be involved in a number of neuropsy chiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.",

author = "Wagner, {Henry N.} and {Donald Burns}, H. and Dannals, {Robert E.} and Wong, {Dean F.} and Bengt Langstrom and Timothy Duelfer and {James Frost}, J. and Ravert, {Hayden T.} and Links, {Jonathan M.} and Rosenbloom, {Shelley B.} and Lukas, {Scott E.} and Kramer, {Alfred V.} and Kuhar, {Michael J.}",

year = "1983",

doi = "10.1126/science.6604315",

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T1 - Imaging dopamine receptors in the human brain by positron tomography

AU - Wagner, Henry N.

AU - Donald Burns, H.

AU - Dannals, Robert E.

AU - Wong, Dean F.

AU - Langstrom, Bengt

AU - Duelfer, Timothy

AU - James Frost, J.

AU - Ravert, Hayden T.

AU - Links, Jonathan M.

AU - Rosenbloom, Shelley B.

AU - Lukas, Scott E.

AU - Kramer, Alfred V.

AU - Kuhar, Michael J.

PY - 1983

Y1 - 1983

N2 - Neurotransmitter receptors may be involved in a number of neuropsy chiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.

AB - Neurotransmitter receptors may be involved in a number of neuropsy chiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.

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U2 - 10.1126/science.6604315

DO - 10.1126/science.6604315

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SN - 0036-8075

VL - 221

SP - 1264

EP - 1266

JO - Science

JF - Science

IS - 4617

ER -

Imaging dopamine receptors in the human brain by positron tomography

Abstract

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