Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Ben Brooksby; Brian W. Pogue; Shudong Jiang; Hamid Dehghani; Subhadra Srinivasan; Christine Kogel; Tor D. Tosteson; John Weaver; Steven P. Poplack; Keith D. Paulsen

doi:10.1073/pnas.0509636103

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Ben Brooksby, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, Christine Kogel, Tor D. Tosteson, John Weaver, Steven P. Poplack, Keith D. Paulsen

Department of Radiology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

Original language	English
Pages (from-to)	8828-8833
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	103
Issue number	23
DOIs	https://doi.org/10.1073/pnas.0509636103
State	Published - Jun 6 2006

Keywords

Fat
Hemoglobin
Magnetic resonance imaging
Oxygen saturation
Water

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10.1073/pnas.0509636103

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Brooksby, B., Pogue, B. W., Jiang, S., Dehghani, H., Srinivasan, S., Kogel, C., Tosteson, T. D., Weaver, J., Poplack, S. P., & Paulsen, K. D. (2006). Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. Proceedings of the National Academy of Sciences of the United States of America, 103(23), 8828-8833. https://doi.org/10.1073/pnas.0509636103

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title = "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography",

abstract = "Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.",

keywords = "Fat, Hemoglobin, Magnetic resonance imaging, Oxygen saturation, Water",

author = "Ben Brooksby and Pogue, {Brian W.} and Shudong Jiang and Hamid Dehghani and Subhadra Srinivasan and Christine Kogel and Tosteson, {Tor D.} and John Weaver and Poplack, {Steven P.} and Paulsen, {Keith D.}",

year = "2006",

month = jun,

day = "6",

doi = "10.1073/pnas.0509636103",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Brooksby, B, Pogue, BW, Jiang, S, Dehghani, H, Srinivasan, S, Kogel, C, Tosteson, TD, Weaver, J, Poplack, SP & Paulsen, KD 2006, 'Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 23, pp. 8828-8833. https://doi.org/10.1073/pnas.0509636103

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. / Brooksby, Ben; Pogue, Brian W.; Jiang, Shudong et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 23, 06.06.2006, p. 8828-8833.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

AU - Brooksby, Ben

AU - Pogue, Brian W.

AU - Jiang, Shudong

AU - Dehghani, Hamid

AU - Srinivasan, Subhadra

AU - Kogel, Christine

AU - Tosteson, Tor D.

AU - Weaver, John

AU - Poplack, Steven P.

AU - Paulsen, Keith D.

PY - 2006/6/6

Y1 - 2006/6/6

N2 - Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

AB - Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

KW - Fat

KW - Hemoglobin

KW - Magnetic resonance imaging

KW - Oxygen saturation

KW - Water

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U2 - 10.1073/pnas.0509636103

DO - 10.1073/pnas.0509636103

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AN - SCOPUS:33745018793

SN - 0027-8424

VL - 103

SP - 8828

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23

ER -

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

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Keywords

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