Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

Dominik Geisel; Lutz Lüdemann; Vera Fröling; Maciej Malinowski; Martin Stockmann; Annekathrin Baron; Bernhard Gebauer; Daniel Seehofer; Vikas Prasad; Timm Denecke

doi:10.1007/s00330-014-3536-8

Imaging-based evaluation of liver function: comparison of ^99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

Dominik Geisel, Lutz Lüdemann, Vera Fröling, Maciej Malinowski, Martin Stockmann, Annekathrin Baron, Bernhard Gebauer, Daniel Seehofer, Vikas Prasad, Timm Denecke

Division of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Objectives: To compare Gd-EOB-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.

Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and ^99mTc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T_max, T_1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.

Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r² = 0.802, p = 0.001) and RE for LLL (r² = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r² = 0.560, p = 0.037) and RE for RLL (r² = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r² = 0.775, p = 0.002).

Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and ^99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.

Key points: • Information about liver function can be acquired with routine Gd-EOB-MRI.

• Gd-EOB-MRI and^99mTc-mebrofenin HBS show elevated function of non-embolized lobe.

• Gd-EOB-MRI and^99mTc-mebrofenin HBS can determine lobar liver function.

Original language	English
Pages (from-to)	1384-1391
Number of pages	8
Journal	European Radiology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1007/s00330-014-3536-8
State	Published - May 1 2015

Keywords

EOB
Gadoxetic acid
Liver function
Mebrofenin scintigraphy
MRI

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@article{4e900e48b8a74b3a991968399eeab7ee,

title = "Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI",

abstract = "Objectives: To compare Gd-EOB-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and Tmax, T1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r2 = 0.802, p = 0.001) and RE for LLL (r2 = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r2 = 0.560, p = 0.037) and RE for RLL (r2 = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r2 = 0.775, p = 0.002).Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.Key points: • Information about liver function can be acquired with routine Gd-EOB-MRI.• Gd-EOB-MRI and99mTc-mebrofenin HBS show elevated function of non-embolized lobe.• Gd-EOB-MRI and99mTc-mebrofenin HBS can determine lobar liver function.",

keywords = "EOB, Gadoxetic acid, Liver function, Mebrofenin scintigraphy, MRI",

author = "Dominik Geisel and Lutz L{\"u}demann and Vera Fr{\"o}ling and Maciej Malinowski and Martin Stockmann and Annekathrin Baron and Bernhard Gebauer and Daniel Seehofer and Vikas Prasad and Timm Denecke",

note = "Publisher Copyright: {\textcopyright} 2014, European Society of Radiology.",

year = "2015",

month = may,

day = "1",

doi = "10.1007/s00330-014-3536-8",

language = "English",

volume = "25",

pages = "1384--1391",

journal = "European Radiology",

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T1 - Imaging-based evaluation of liver function

T2 - comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

AU - Geisel, Dominik

AU - Lüdemann, Lutz

AU - Fröling, Vera

AU - Malinowski, Maciej

AU - Stockmann, Martin

AU - Baron, Annekathrin

AU - Gebauer, Bernhard

AU - Seehofer, Daniel

AU - Prasad, Vikas

AU - Denecke, Timm

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objectives: To compare Gd-EOB-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and Tmax, T1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r2 = 0.802, p = 0.001) and RE for LLL (r2 = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r2 = 0.560, p = 0.037) and RE for RLL (r2 = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r2 = 0.775, p = 0.002).Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.Key points: • Information about liver function can be acquired with routine Gd-EOB-MRI.• Gd-EOB-MRI and99mTc-mebrofenin HBS show elevated function of non-embolized lobe.• Gd-EOB-MRI and99mTc-mebrofenin HBS can determine lobar liver function.

AB - Objectives: To compare Gd-EOB-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and Tmax, T1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r2 = 0.802, p = 0.001) and RE for LLL (r2 = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r2 = 0.560, p = 0.037) and RE for RLL (r2 = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r2 = 0.775, p = 0.002).Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.Key points: • Information about liver function can be acquired with routine Gd-EOB-MRI.• Gd-EOB-MRI and99mTc-mebrofenin HBS show elevated function of non-embolized lobe.• Gd-EOB-MRI and99mTc-mebrofenin HBS can determine lobar liver function.

KW - EOB

KW - Gadoxetic acid

KW - Liver function

KW - Mebrofenin scintigraphy

KW - MRI

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JO - European Radiology

JF - European Radiology

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Imaging-based evaluation of liver function: comparison of ^99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

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Keywords

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