Image-based modeling and precision medicine: Patient-specific carotid and coronary plaque assessment and predictions

Dalin Tang, Chun Yang, Jie Zheng, Gador Canton, Richard G. Bach, Thomas S. Hatsukami, Liang Wang, Deshan Yang, Kristen L. Billiar, Chun Yuan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Atherosclerotic plaques may rupture without warning and cause acute cardiovascular events such as heart attack and stroke. Current clinical screening tools are insufficient to identify those patients with risks early and prevent the adverse events from happening.Medical imaging and image-based modeling have made considerable progress in recent years in identifying plaque morphological and mechanical risk factors which may be used in developing improved patient screening strategies. The key steps and factors in image-based models for human carotid and coronary plaques were illustrated, as well as grand challenges facing the researchers in the field to develop more accurate screening tools.

Original languageEnglish
Pages (from-to)643-651
Number of pages9
JournalIEEE Transactions on Biomedical Engineering
Volume60
Issue number3
DOIs
StatePublished - 2013

Keywords

  • Atherosclerosis
  • Fluid-structure interaction (FSI)
  • Intravascular ultrasound (IVUS)-based modeling
  • MRI-based modeling
  • Vulnerable plaques

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