Image based feasibility of renal sparing surgery for very low risk unilateral wilms tumors: A report from the children's oncology group

F. A. Ferrer, N. Rosen, K. Herbst, C. V. Fernandez, G. Khanna, J. S. Dome, E. Mullen, K. W. Gow, D. C. Barnhart, R. C. Shamberger, M. Ritchey, P. Ehrlich

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Abstract

Purpose: Nephrectomy with lymph node sampling is the recommended treatment for children with unilateral Wilms tumor under the Children's Oncology Group protocols. Using radiological assessment, we determined the feasibility of performing partial nephrectomy in a select group of patients with very low risk unilateral Wilms tumor. Materials and Methods: We reviewed imaging studies of 60 patients with a mean age of less than 2 years with very low risk unilateral Wilms tumor (mean weight less than 550 gm) to assess the feasibility of partial nephrectomy. We evaluated percentage of salvageable parenchyma, tumor location and anatomical features preventing a nephron sparing approach. Results: A linear relationship exists between tumor weight and computerized tomography estimated tumor volume. Mean tumor weight in the study population was 315 gm. Partial nephrectomy was deemed feasible in only 5 of 60 patients (8%). Conclusions: When considering a select population with very low risk unilateral Wilms tumor (lower volume tumor), only a small percentage of nonpretreated patients are candidates for nephron sparing surgery.

Original languageEnglish
Pages (from-to)1846-1851
Number of pages6
JournalJournal of Urology
Volume190
Issue number5
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Diagnostic imaging
  • Kidney neoplasms
  • Nephrectomy
  • Wilms tumor

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    Ferrer, F. A., Rosen, N., Herbst, K., Fernandez, C. V., Khanna, G., Dome, J. S., Mullen, E., Gow, K. W., Barnhart, D. C., Shamberger, R. C., Ritchey, M., & Ehrlich, P. (2013). Image based feasibility of renal sparing surgery for very low risk unilateral wilms tumors: A report from the children's oncology group. Journal of Urology, 190(5), 1846-1851. https://doi.org/10.1016/j.juro.2013.05.060