A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.

Original languageEnglish
Article numberofab256
JournalOpen Forum Infectious Diseases
Issue number6
StatePublished - Jun 1 2021


  • Trichosporon
  • fungal infection
  • immunotherapy
  • interleukin-7
  • wound infection


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