IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis

Isaiah R. Turnbull; Monty B. Mazer; Mark H. Hoofnagle; John P. Kirby; Jennifer M. Leonard; Carlos Mejia-Chew; Andrej Spec; Jane Blood; Sydney M. Miles; Eric M. Ransom; Robert F. Potter; Joseph P. Gaut; Kenneth E. Remy; Richard S. Hotchkiss

doi:10.1093/ofid/ofab256

IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis

Isaiah R. Turnbull, Monty B. Mazer, Mark H. Hoofnagle, John P. Kirby, Jennifer M. Leonard, Carlos Mejia-Chew, Andrej Spec, Jane Blood, Sydney M. Miles, Eric M. Ransom, Robert F. Potter, Joseph P. Gaut, Kenneth E. Remy, Richard S. Hotchkiss

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16 Scopus citations

Abstract

A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.

Original language	English
Article number	ofab256
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	6
DOIs	https://doi.org/10.1093/ofid/ofab256
State	Published - Jun 1 2021

Keywords

Trichosporon
fungal infection
immunotherapy
interleukin-7
wound infection

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Turnbull, I. R., Mazer, M. B., Hoofnagle, M. H., Kirby, J. P., Leonard, J. M., Mejia-Chew, C., Spec, A., Blood, J., Miles, S. M., Ransom, E. M., Potter, R. F., Gaut, J. P., Remy, K. E., & Hotchkiss, R. S. (2021). IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis. Open Forum Infectious Diseases, 8(6), Article ofab256. https://doi.org/10.1093/ofid/ofab256

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abstract = "A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.",

keywords = "Trichosporon, fungal infection, immunotherapy, interleukin-7, wound infection",

author = "Turnbull, {Isaiah R.} and Mazer, {Monty B.} and Hoofnagle, {Mark H.} and Kirby, {John P.} and Leonard, {Jennifer M.} and Carlos Mejia-Chew and Andrej Spec and Jane Blood and Miles, {Sydney M.} and Ransom, {Eric M.} and Potter, {Robert F.} and Gaut, {Joseph P.} and Remy, {Kenneth E.} and Hotchkiss, {Richard S.}",

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doi = "10.1093/ofid/ofab256",

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AU - Turnbull, Isaiah R.

AU - Mazer, Monty B.

AU - Hoofnagle, Mark H.

AU - Kirby, John P.

AU - Leonard, Jennifer M.

AU - Mejia-Chew, Carlos

AU - Spec, Andrej

AU - Blood, Jane

AU - Miles, Sydney M.

AU - Ransom, Eric M.

AU - Potter, Robert F.

AU - Gaut, Joseph P.

AU - Remy, Kenneth E.

AU - Hotchkiss, Richard S.

PY - 2021/6/1

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N2 - A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.

AB - A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.

KW - Trichosporon

KW - fungal infection

KW - immunotherapy

KW - interleukin-7

KW - wound infection

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ER -

IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis

Abstract

Keywords

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