IL-5 Receptor Expression and Ig Secretion from Murine B Lymphocytes Requires Coordinated Signaling by Membrane Ig, IL-4, and IL-5

Jason D. Weber, Peter C. Isakson, Jeffrey M. Purkerson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Interleukin-5 plays a pivotal role in the regulation of Ig secretion from murine B cells. Resting B cells express few, if any, IL-5 receptors and do not respond to the lymphokine. Culture of resting B cells with IL-4 induced expression of the IL-5R α-chain, while signaling through membrane Ig stimulated expression of the IL-5R β-chain. Surprisingly, IL-4 suppressed expression of the β-chain on activated B cells and inhibited responsiveness to IL-5 in subsequent cultures. Simultaneous culture of B lymphoblasts with IL-4 and IL-5 elicited sustained expression of the β-chain and promoted secretion of IgM. Thus, expression of IL-5 receptors and induction of Ig secretion requires coordination of signals provided by membrane Ig, IL-4, and IL-5.

Original languageEnglish
Pages (from-to)4428-4435
Number of pages8
JournalJournal of Immunology
Volume157
Issue number10
StatePublished - Nov 15 1996

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